Adipose tissue is a key regulator of C-reactive protein (CRP), an inflammatory marker linked to atherosclerosis. Adiponectin, the most abundant adipokine is also an importantl factor involved in the inflammatory state of obesity. The aim of the study was to assess the impact of gastric bypass surgery (GBS) on the CRP levels and its relation […]
Background: Effective non-surgical treatment of morbid obesity continues to elude the medical community. Capturing positive effects of Roux-en-Y gastric bypass (RYGB) without surgery may be essential in achieving this goal. We have previously shown that patients experience taste changes and aversions following RYGB. A rat model for RYGB can help define these changes as physiological […]
Background: Following Roux-en-Y gastric bypass (RYGB), hyperglycemia dramatically improves in obese patients with Type II diabetes (T2D). For many patients, hypoglycemic agents and insulin are discontinued after RYGB. However, the exact mechanisms of this process are unknown. This unique study attempts to identify differences in gene expression profiles between pre- and post-operative T2D patients following […]
Introduction: Minimally Invasive Surgery (MIS) leads to a reduced sense of touch and diminished haptics (force feedback) in comparison to open surgery. This increases the potential for excessive force application during tissue manipulation. There are little data regarding tissue damage resulting from forces routinely applied in MIS. The purpose of this study is to systematically […]
Background: The causes of obesity are multifactorial and may include dysregulation of certain genes, such as peroxisome proliferator activated receptor gamma (PPAR gamma). When activated, the PPAR gamma pathway promotes lipid metabolism. This study uses microarray technology to evaluate differential gene expression profiles in obese patients undergoing bariatric surgery versus non-obese controls. Methods: Blood samples […]