Topic: Physiology

Role of Interleukin-6 (il-6) in the Growth of Ct26 Colorectal Cancer in a Murine Model

PURPOSE: This study is designed to investigate the role of surgery-induced levels of cytokines in affecting proliferation and migration of colon cancer cells. Clinical standards in the management of colon cancer and surgery-related differences in various cytokines have been predicted to correlate with the degree of trauma afflicted during surgery, ultimately impacting tumor growth and […]

Analysis of Tissue Damage Caused By Ultrasonically Activated Device for Laparoscopic Surgeries

Introduction: It has been known that ultrasonically activated devices (USAD) cause tissue planes to separate ahead of the blade tip and described as “distal drilling” phenomenon of the device seen during surgeries. “Cavitational bubbles” generated under transient fluctuation of pressure within tissues have been thought to account for this phenomenon. Meanwhile, collapse of cavitation bubbles […]

3-ccd (charge Coupled Device) Image Enhancement for Bowel Ischemia

Introduction: Determination of bowel perfusion in cases of strangulating hernias, SMA occlusion, and other ischemic states is currently a subjective decision of surgeons. 3-CCD image enhancement allows objective and quantitative criteria to be included in a surgeon’s decision as to whether bowel resection is warranted secondary to ischemia. 3-CCD technology separates visible light into its […]

Human Vital Amniotic Membrane Reduces Adhesions to a Polypropylene Mesh and Suture Fixation in Experimental Ipom Repair in Rats

Introduction: Various coatings have been proposed to avoid adhesion formation to meshes and fixation devices used for intraabdominal peritoneal onlay repair (IPOM). Despite the undeniable progress of product development in the field, related complications such as ileus and pain are still frequent. Avital amniotic membrane (AM) has been used as an effective anti-adhesive coating in […]

Efficacy of Turmeric (curcumin) in Pain and Postoperative Fatigue After Laparoscopic Cholecystectomy – a Double Blind, Randomized Placebo Controlled Study

Objective of StudyPopularity of laparoscopic surgery owes largely to improved patient reported outcomes (PRO). Postoperative pain and fatigue are important indices of return to activity based quality of life PROs. Turmeric has been successfully used in India as a monotherapy for traumatic pain & fatigue. Curcumin, the active ingredient of turmeric has anti-inflammatory / anti-oxidant […]

Day to Day Discrepancy in Bravo Capsule Ph Monitoring: The Impact of Manometric Placement and Status of Lower Esophageal Sphincter

Introduction: The wireless esophageal pH monitoring (Bravo Capsule) is better tolerated and allows longer period of recording (2 days or more) in patients evaluated for gastroesophageal reflux disease. The use of this system may result in day to day discrepancy in measurement of distal esophageal acid exposure. This variation is thought to be due to […]

Collagen Type I/III Ratio in the Supporting Ligaments of the Gastroesophageal Junction in Patients with Paraesophageal Hernias

Introduction: The purpose of this study was to examine the biologic environment of the esophageal hiatus through analysis of the collagen content within the gastrohepatic ligament (GHL), gastrophrenic ligament (GPL), and phrenoesophageal ligament (PEL) in patients with Type III paraesophageal hernias (PEH). Methods: A control group (N=10) with achalasia and patients (N=10) with Type III […]

Creation of a Sleeve Gastrectomy Mouse Model: a New Tool in the Evaluation of the Beta Cell Proliferation and Glucose Tolerance Effects of Bariatric Surgery

Evaluation of the Beta Cell Proliferation and Glucose Tolerance Effects of Bariatric Surgery Abstract Introduction: The recent discovery of enhanced glucose tolerance following bariatric surgery has sparked renewed interest in investigation of unchartered underlying pathways of glucose homeostasis. It is hoped that delineation of the active pathway effected by bariatric surgery may be the first […]

Downregulation of Leptin and Resistin Expression in Blood Following Bariatric Surgery

Introduction: Morbidly obese patients are at increased risk for developing type 2 diabetes (T2D). Interestingly, T2D resolves rapidly after bariatric surgery, even before substantial weight is lost. However, the underlying molecular pathways by which T2D resolves after bariatric surgery remain unclear. Previous microarray data has shown the genes for leptin and resistin are differentially expressed […]

Cholecystectomy By Microlaparotomy-As the Precursor of Single Incision Laparoscopic Surgery- Comparing to Standard Laparoscopic Cholecystectomy (in Honour of Two Hungarian Surgeons)

It is less known that at the beginning of laparoscopic era, two Hungarian surgeons, G. Jako and I. Rozsos, developed a new minimally invasive method for the removal of the gallbladder performed through the abdominal wall, using a similarly small 2.5-3 cm incision as that of the transumbilical single incision laparoscopic procedure. The technique called […]

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