BILE REFLUX INDUCED MUTAGENESIS ON ESOPHAGEAL EPITHELIUM IN AN ANIMAL MODEL AND ITS EFFECT IN CELL SIGNALING Ben Selvan MS, Anu Korula MD, Anoop Ramachandran PhD, Jaya kumar MSc, Sathish Kumar MSc, George MS, Christian Medical College ,Vellore Background: . Bile reflux has been suggested to have a mutagenic effect on esophageal epithelium. However, signaling […]
Introduction:24 hour esophageal pH is the most widely used method to quantify Gastroesophageal reflux (GER). GER may potentially be underestimated if the resting gastric pH is high. However, the value of routine assessment of gastric pH in the performance of 24hr esophageal pH monitoring is unclear. We studied normal subjects and symptomatic patients undergoing 24 […]
Introduction:The physiopathologic consequences of pneumoperitoneum are well known. In the attempt to minimize CO2 peritonel uptake and the related physiological consequences, a new generation of insufflation systems and trocars are in development. This experimental animal study aims to assess the applicability and safety of a new insufflation and trocar system for laparoscopic surgery: the AirSeal […]
Objective: Current evidence suggests that the neurotransmitter Nitric Oxide (NO) plays a crucial role in the genesis of aboral propagative of esophageal peristalses during swallowing. However, direct evidence in this regard is lacking at present. The objective of this study was to measure changes in the level of NO within the intermuscular interstices of esophagus […]
Introduction: Critics of minimally invasive methods sometimes argue that the sum of lengths of all trocar sites are similarly morbid to a “conventional” incision of equal length. This argument assumes correctly that pain and scarring are proportional to total tension normal to a linear incision. But the argument also assumes that total tension sums linearly […]