Despite recent studies1,2 investigating different closure techniques following laparotomy, the incidence of incisional hernia remains high. A common cause of failure
Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) is effective as a temporizing measure in non-compressible truncal hemorrhage (NCTH). However, use
The treatment options for cancer are ever-evolving and now include vaccines targeting tumor-specific immunogenic peptides to induce tumor cytolysis. Folate bindin
Hemorrhagic shock as a result of trauma or surgical bleeding is frequently temporized with administration of vasopressors in order to augment systemic vascular resistan
The autologous tumor lysate, particle loaded, dendritic cell (TLPLDC) vaccine has been previously shown to be safe and immunogenic while producing objective tumor respon
Traumatic coagulopathy has now been well characterized, but still carries high rates of mortality due to bleeding. A "factor-based" resuscitation strategy usin
Mitochondria is a small energy producing structure of a cell. Mitochondrial myopathy (MM) is mixed disorder clinically, which can affect various systems besides skele
The ultrasonic dissector, commonly known as the harmonic scalpel, has been in use for achieving haemostasis in surgery for almost 20 yrs. Its advantages in breast surge
OBJECTIVES: Activation of toll-like receptor 4 (TLR-4) by damage associated molecular patterns (DAMPs) has been implicated in the systemic activation of the immune system in hemorr
Objectives: Tension pneumothorax (tPTX) is the second most common cause of preventable death in trauma. Needle decompression is the first-line intervention but has high failure rat
Objectives. Trauma accounts for ~50% of combat-related deaths. Rapid blood loss from trauma can lead to hemorrhagic shock resulting in organ damage. Renal functio
Non-compressible truncal hemorrhage can be temporarily controlled using resuscitative endovascular occlusion of the aorta (REBOA). Prolonged ischemia has limite
Adhesion formation after laparotomy remains a major cause of post-operative morbidity. Hyaluronate/carboxymethylcellulose membranes (HAC) are costly bioresorbable mem
OBJECTIVES: E39 (FBP191-199,GALE-301,EIWTHSYKV) is a FBP-derived peptide vaccine shown to be safe and efficacious in a phase I/IIa trial. Due to concerns of overstimulation w
Negative pressure wound therapy (NPWT) aims to improve healing by secondary intention of acute and/or chronic wounds by dynamic vacuum assisted removal of wound ex
OBJECTIVES: Gulf War Illness (GWI) is a chronic, multisymptom illness marked by cognitive and mood dysfunction and disrupted neuroendocrine-immune homeostasis affecting 30% of GW v
Keywords: microRNA-17; Cancer; Outcome; Prognosis; Meta-analysis.
Background: The recognition of biomarkers to predict the outcome of caner is in need. M
Adhesions are a cause of morbidity following surgery. Multiple approaches have been evaluated to minimize them. Aerosolized heparin and hyaluronic acid is an effectiv
Neoadjuvant chemoradiation (CRT) for rectal cancer induces variable responses, and better response has been associated with improved oncologic outcomes. Our group has
Adenocarcinoma of the proximal stomach is the fastest rising malignancy in North America, and is associated with a high rate of recurrence to the peritoneum. As part of cancer treatment, the majori
Sleeve gastrectomy is regarded as an effective intervention for both obesity and comorbid conditions such as diabetes. However, the mechanisms underlying diabetes remi
Gastric cancer (GC) is the second leading cause of cancer-related death wordwide. AFAP1-AS1, a long noncoding RNA (lncRNA), is believed to promote an aggressive progress
Sophisticated body armor and advanced combat casualty care have improved survival after catastrophic extremity and maxillofacial trauma. Vascularized composite allotran
Sleeve gastrectomy has become more popular in a surgical procedure to treat patients with morbid obesity. An essential part of the procedure is the hemostasis on the