BACKGROUND: The most common cause of hepatic iron overload is a genetic mutation (C282Y) that causes an increase in serum transferrin saturation and ferritin levels. Abnormalities in iron metabolism as well as nonalcoholic steatosis are known conditions associated with obesity. The purpose of this study was to analyze the hepatic DNA of morbidly obese patients […]
Background: Laparoscopic surgery has been shown to decrease systemic stress compared to open abdominal surgery. One of the mechanisms to explain this finding is the effect of carbon dioxide (CO2) as an insufflation gas. Previous studies have shown that peritoneal exposure to CO2 results in a suppressed inflammatory response compared to air exposure. With the […]
Background: Nowadays, laparoscopic surgery has feasibility of partial liver resection and pancreatectomy because of less invasion than a conventional open operation. It is known increased intra-abdominal pressure on the liver and on the pancreas induce reduction of micro- and macro-circulation and this cause severe damage on splanchnic organs. However there is not enough monitoring method […]
Background: Minimally-invasive surgery is associated with a decreased activation of both systemic and peritoneal immunity as compared to the open (O) technique. However, the hepatic response to laparoscopic (L) and hand-assisted (HA) surgery has not been defined well. We postulated that both laparoscopic and hand-assisted approaches are associated with a diminished expression of hepatic pro-inflammatory […]
Study Aim: The risk of gastric spillage during transgastric surgery is a concerning potential complication of NOTES procedures. The aim of this study is to determine the risk of sepsis from gastric spillage in a rat survival model by measuring local and systemic inflammatory markers, adhesive disease, and clinical outcomes.Methods: Under IACUC approval, mini-laparotomy with […]