Adipose tissue is the most abundant endocrine tissue in the body, producing leptin, a hormone important in regulating hunger, and adiponectin, a hormone involved in insulin sensitivity and inflammation. The aim of this study was to assess the impact of gastric bypass surgery (GBS) on leptin levels and its relation to omental adiponectin expression. Methods: […]
Background: Pathologically, hepatic changes are common in morbidly obese patients. Insulin resistance impacts the pathogenesis of non-alcoholic fatty liver disease and may potentiate the progression of non-alcoholic steatohepatits and fibrosis. This study investigates the impact of leptin and adiponectin in morbidly obese diabetic and non-diabetic patients with regards to histopathological hepatic changes. Methods: Twenty morbidly […]
INTRODUCTION: Vessel sealing devices of 5 mm in diameter for laparoscopic surgery provide only a small breadth of sealing area. Therefore, various double sealing techniques have been tried to enhance bursting pressure of the sealed vessels by surgeons. However, there have been no reports to reveal which technique achieved best performance of vessel sealing. Those […]
INTRODUCTION: We hypothesize that various biologic and biodegradable meshes (BM) differentially induce macrophage (MØ) activation in vitro. Inflammation and wound healing play critical roles in the integration of biologic and biodegradable meshes (BM) at the sites of hernia repair. Macrophages (MØ) are the key cells controlling inflammation and wound healing. Interleukin-1beta (IL-1b), IL-6, and IL-8 […]
Introduction: Ligamentous attachments maintain the normal anatomical position of the gastroesophageal (GE) junction. Failure of these elastic ligaments through an alteration in collagen synthesis, deposition and metabolism may be a primary etiology of hiatal hernia formation. Differential expression of zinc-dependent matrix metalloproteinases (MMPs) is largely responsible for collagen remodeling. The purpose of this study was […]