The Impact of Co2-pneumoperitoneum on Liver Regeneration After Liver Resection in a Rat Model.

Introduction
During the past years, laparoscopic hepatic resection is beeing performed by an increasing number of surgeons. Despite many advantages of the laparoscopic procedure, it is unclear if the pneumoperitoneum affects the postoperative liver regeneration after liver resection. The aim of the present study was to investigate the influence of a CO2-pneumoperitoneum (PP) on liver regeneration in a rat model.
Methods
60 male wistar rats were subjected to 70% partial hepatic resection. 30 of these animals underwent preoperative PP with 9 mm Hg for 60 minutes. After hepatic resection, rats were killed at 12, 24, 48 hours, 4 and 7 days. Outcome parameters were: hepatocellular injury (plasma aminotransferases), oxidative stress (malondialdehyd) and liver regeneration (mitotic index, KI-67, regenerating liver mass).
Results
Mitotic index was significantly lower in the PP group compared with the group without PP at all time points (p


Session: Podium Presentation

Program Number: S052

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