• Skip to main content
  • Skip to header right navigation
  • Skip to site footer

Log in
  • Search
    • Search All SAGES Content
    • Search SAGES Guidelines
    • Search the Video Library
    • Search the Image Library
    • Search the Abstracts Archive
www.sages.org

SAGES

Reimagining surgical care for a healthier world

  • Home
    • Search
    • SAGES Home
    • SAGES Foundation Home
  • About
    • Awards
    • Who Is SAGES?
    • Leadership
    • Our Mission
    • Advocacy
    • Committees
      • SAGES Board of Governors
      • Officers and Representatives of the Society
      • Committee Chairs and Co-Chairs
      • Committee Rosters
      • SAGES Past Presidents
  • Meetings
    • SAGES NBT Innovation Weekend
    • SAGES Annual Meeting
      • 2026 Scientific Session Call for Abstracts
      • 2026 Emerging Technology Call for Abstracts
    • CME Claim Form
    • SAGES Past, Present, Future, and Related Meeting Information
    • SAGES Related Meetings & Events Calendar
  • Join SAGES!
    • Membership Application
    • Membership Benefits
    • Membership Types
      • Requirements and Applications for Active Membership in SAGES
      • Requirements and Applications for Affiliate Membership in SAGES
      • Requirements and Applications for Associate Active Membership in SAGES
      • Requirements and Applications for Candidate Membership in SAGES
      • Requirements and Applications for International Membership in SAGES
      • Requirements for Medical Student Membership
    • Member Spotlight
    • Give the Gift of SAGES Membership
  • Patients
    • Join the SAGES Patient Partner Network (PPN)
    • Patient Information Brochures
    • Healthy Sooner – Patient Information for Minimally Invasive Surgery
    • Choosing Wisely – An Initiative of the ABIM Foundation
    • All in the Recovery: Colorectal Cancer Alliance
    • Find A SAGES Surgeon
  • Publications
    • Clinical / Practice / Training Guidelines, Statements, and Standards of Practice
    • Sustainability in Surgical Practice
    • SAGES Stories Podcast
    • Patient Information Brochures
    • Patient Information From SAGES
    • TAVAC – Technology and Value Assessments
    • Surgical Endoscopy and Other Journal Information
    • SAGES Manuals
    • MesSAGES – The SAGES Newsletter
    • COVID-19 Archive
    • Troubleshooting Guides
  • Education
    • Wellness Resources – You Are Not Alone
    • Avoid Opiates After Surgery
    • SAGES Subscription Catalog
    • SAGES TV: Home of SAGES Surgical Videos
    • The SAGES Safe Cholecystectomy Program
    • Masters Program
    • Resident and Fellow Opportunities
      • MIS Fellows Course
      • SAGES Robotics Residents and Fellows Courses
      • SAGES Free Resident Webinar Series
      • Fluorescence-Guided Surgery Course for Fellows
      • Fellows’ Career Development Course
    • SAGES S.M.A.R.T. Enhanced Recovery Program
    • SAGES @ Cine-Med Products
      • SAGES Top 21 Minimally Invasive Procedures Every Practicing Surgeon Should Know
      • SAGES Pearls Step-by-Step
      • SAGES Flexible Endoscopy 101
    • SAGES OR SAFETY Video Activity
  • Opportunities
    • Fellowship Recognition Opportunities
    • SAGES Advanced Flexible Endoscopy Area of Concentrated Training (ACT) SEAL
    • Multi-Society Foregut Fellowship Certification
    • Research Opportunities
    • FLS
    • FES
    • FUSE
    • Jobs Board
    • SAGES Go Global: Global Affairs and Humanitarian Efforts
  • OWLS/FLS
You are here: Home / Abstracts / Randomized Trial of Ofirmev Versus Placebo After Laparoscopic Sleeve Gastrectomy

Randomized Trial of Ofirmev Versus Placebo After Laparoscopic Sleeve Gastrectomy

Matthew A Strode, DO, William Sherman, MD, Chris Bland, PharmD, Preston Sparks, DO, Byron Faler, MD, Yong Choi, MD. Eisenhower Army Medical Center.

INTRODUCTION: Ofirmev is an intravenous form of Acetaminophen approved by the FDA in 2010. The indicated uses include the treatment of pain with and without the use of opioids. Several studies have administered Ofirmev in an attempt to reduce the amount of narcotics used in post-operative patients with mixed results. A meta-analysis reported decreased opioid usage in 10 of 14 studies of intravenous Acetaminophen compared with placebo. We designed a randomized control trial using Ofirmev versus placebo in conjunction with single narcotic patient-controlled analgesia (PCA) in post-operative laparoscopic sleeve gastrectomy (LSG) patients for twenty-four hours.

METHODS AND PROCEDURES: 19 patients which met criteria for LSG were enrolled and randomized into 2 separate limbs of the study. The Ofirmev and placebo group had similar mean age ranges (54.6 +/- 2.4 and 51.0 +/- 4.8, respectively) and male: female ratio (3:8 and 2:6, respectively.) The patients received postoperative administration of intravenous Ofirmev 1gram every 6 hours for 24 hours in addition to single narcotic PCA. The remaining 8 patients received intravenous placebo administered at the same time intervals also with a single narcotic PCA. At the conclusion of 24 hours, the total amount of narcotic was recorded. Secondary endpoints included the measurement of liver function tests at 24 hours and 48 hours post-operatively.

RESULTS: In our interim analysis, patients receiving Ofirmev trended towards increased narcotic use at 24 hours compared with the placebo group, but this did not meet statistical significance. There has been no consistent relationship of the elevation of liver function tests and the administration of Ofirmev or placebo

CONCLUSION: At this time, it appears that early in our study that the Orfirmev group has a trend towards increased narcotic use at 24 hours post-operatively compared with placebo. Further patient enrollment will hopefully elucidate the relationship between our two study groups.

 

View Poster

200

Share this:

  • Click to share on X (Opens in new window) X
  • Click to share on Facebook (Opens in new window) Facebook
  • Click to share on LinkedIn (Opens in new window) LinkedIn
  • Click to share on Pinterest (Opens in new window) Pinterest
  • Click to share on WhatsApp (Opens in new window) WhatsApp
  • Click to share on Reddit (Opens in new window) Reddit
  • Click to share on Pocket (Opens in new window) Pocket
  • Click to share on Mastodon (Opens in new window) Mastodon
  • Click to share on Threads (Opens in new window) Threads
  • Click to share on Bluesky (Opens in new window) Bluesky

Related


sages_adbutler_leaderboard

Hours & Info

11300 West Olympic Blvd, Suite 600
Los Angeles, CA 90064

1-310-437-0544

[email protected]

Monday – Friday
8am to 5pm Pacific Time

Find Us Around the Web!

  • Bluesky
  • X
  • Instagram
  • Facebook
  • YouTube

Copyright © 2025 · SAGES · All Rights Reserved

Important Links

Healthy Sooner: Patient Information

SAGES Guidelines, Statements, & Standards of Practice

SAGES Manuals