• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
  • Skip to footer

SAGES

Reimagining surgical care for a healthier world

  • Home
    • COVID-19 Annoucements
    • Search
    • SAGES Home
    • SAGES Foundation Home
  • About
    • Who is SAGES?
    • SAGES Mission Statement
    • Strategic Plan, 2020-2023
    • Committees
      • Request to Join a SAGES Committee
      • SAGES Board of Governors
      • Officers and Representatives of the Society
      • Committee Chairs and Co-Chairs
      • Full Committee Rosters
      • SAGES Past Presidents
    • Donate to the SAGES Foundation
    • Awards
      • George Berci Award
      • Pioneer in Surgical Endoscopy
      • Excellence In Clinical Care
      • International Ambassador
      • IRCAD Visiting Fellowship
      • Social Justice and Health Equity
      • Excellence in Community Surgery
      • Distinguished Service
      • Early Career Researcher
      • Researcher in Training
      • Jeff Ponsky Master Educator
      • Excellence in Medical Leadership
      • Barbara Berci Memorial Award
      • Brandeis Scholarship
      • Advocacy Summit
      • RAFT Annual Meeting Abstract Contest and Awards
  • Meetings
    • 2022 NBT Innovation Weekend
    • SAGES Annual Meeting
      • 2023 Scientific Session Call For Abstracts
      • 2023 Emerging Technology Call For Abstracts
    • SAGES 2021 Annual Meeting
    • CME Claim Form
    • Industry
      • Advertising Opportunities
      • Exhibit Opportunities
      • Sponsorship Opportunities
    • Future Meetings
    • Past Meetings
      • SAGES 2021
      • SAGES 2020
      • SAGES 2019
      • SAGES 2018
    • Related Meetings Calendar
  • Join SAGES!
    • Membership Benefits
    • Membership Applications
      • Active Membership
      • Affiliate Membership
      • Associate Active Membership
      • Candidate Membership
      • International Membership
      • Medical Student Membership
    • Member News
      • Member Spotlight
      • Give the Gift of SAGES Membership
  • Patients
    • Healthy Sooner – Patient Information for Minimally Invasive Surgery
    • Patient Information Brochures
    • Choosing Wisely – An Initiative of the ABIM Foundation
    • All in the Recovery: Colorectal Cancer Alliance
    • Find a SAGES Member
  • Publications
    • SAGES Stories Podcast
    • SAGES Clinical / Practice / Training Guidelines, Statements, and Standards of Practice
    • Patient Information Brochures
    • TAVAC – Technology and Value Assessments
    • Surgical Endoscopy and Other Journal Information
    • SAGES Manuals
    • SCOPE – The SAGES Newsletter
    • COVID-19 Annoucements
    • Troubleshooting Guides
  • Education
    • OpiVoid.org
    • SAGES.TV Video Library
    • Safe Cholecystectomy Program
      • Safe Cholecystectomy Didactic Modules
    • Masters Program
      • SAGES Facebook Program Collaboratives
      • Acute Care Surgery
      • Bariatric
      • Biliary
      • Colorectal
      • Flexible Endoscopy (upper or lower)
      • Foregut
      • Hernia
      • Robotics
    • Educational Opportunities
    • HPB/Solid Organ Program
    • Courses for Residents
      • Advanced Courses
      • Basic Courses
    • Video Based Assessments (VBA)
    • Robotics Fellows Course
    • MIS Fellows Course
    • Facebook Livestreams
    • Free Webinars For Residents
    • SMART Enhanced Recovery Program
    • SAGES OR SAFETY Video
    • SAGES at Cine-Med
      • SAGES Top 21 MIS Procedures
      • SAGES Pearls
      • SAGES Flexible Endoscopy 101
      • SAGES Tips & Tricks of the Top 21
  • Opportunities
    • SAGES Fellowship Certification for Advanced GI MIS and Comprehensive Flexible Endoscopy
    • Foregut Fellowship Certification
    • SAGES Research Opportunities
    • Fundamentals of Laparoscopic Surgery
    • Fundamentals of Endoscopic Surgery
    • Fundamental Use of Surgical Energy
    • Job Board
    • SAGES Go Global: Global Affairs and Humanitarian Efforts
  • Search
    • Search All SAGES Content
    • Search SAGES Guidelines
    • Search the Video Library
    • Search the Image Library
    • Search the Abstracts Archive
  • Store
    • SAGES Logo Products
    • “Unofficial” Logo Products
  • Log In

MICR is associated with elevated plasma levels of MMP2 during the 1st month after surgery which may promote tumor growth & metastasis

Hmc Shantha Kumara, PhD1, Hiromichi Miyagaki, MDPhD2, Charles Petrick, BS1, Xiaohong Yan, MDPhD1, Linda Njoh, PhD1, Vesna Cekic, RN1, Nipa D Gandhi, MD1, Richard L Whelan, MD1. 1Department of Surgery, Mount Sinai Roosvelt Hospital, New York, USA, 2Department of Gastroenterological surgery,Osaka University,Osaka,Japan,

Introduction: Matrix Metalloproteinase -2(MMP-2) degrades type IV collagen, a major component of basement membranes. MMP-2 plays important roles in tissue remodeling and wound healing but has also been implicated in disease processes including cancer. Elevated MMP-2 activity has been linked to a poor prognosis in lung, breast, prostate and colorectal cancer (CRC). MMP-2, by degrading basement membrane, facilitates tumor cell invasion and metastasis formation.  MMP-2 is also thought to promote tumor angiogenesis by facilitating Endothelial Cell migration and VEGF release. The impact of minimally invasive colorectal resection (MICR) for CRC on plasma MMP-2 levels is unknown. This study’s aim was to measure plasma MMP-2 levels during the first postoperative (postop) month.

Method: CRC patients undergoing MICR who were enrolled in an IRB approved data/plasma bank for whom adequate plasma samples were available were eligible. Prospectively gathered clinical, operative and pathological data were utilized. Blood samples were collected Preop and at varying postop time points and were stored at -80C. Only patients for whom Preop, Postop day (POD) 1, 3 and at least 1 late postop plasma sample (POD 7-41) were available were included in the study. The late samples were bundled into 7 day time blocks and considered as single time points. MMP-2 levels were analyzed in duplicate via ELISA and the results reported as mean and ±SD .The paired t-test was used for analysis. (Significance,  p<0.008 after Bonferroni’s correction).

Results: A total of 101 CRC (rectal, 27%; colon, 63%) patients that underwent MICR were studied (51 males /49 female, mean age 66.5± 12.8 years). The mean incision length was 8.2 ± 4.2cm and mean LOS 6.8± 4.1 days. The cancer stage breakdown was: Stage I, 34%; Stage II, 29%; stage III, 33%; and stage IV, 5%.The mean PreOp MMP-2 level (ng/ml) was 176.8±40.6 (n=101). Significantly elevated mean plasma levels were noted on POD1 (213.0±49.2, n=100,p=< 0.0001), POD3 (256.3±65.9,n=90,p=< 0.0001), POD7-13(227.5±60.2,n=75,p=< 0.0001), POD 14-20 (236.0±45.9,n=29,p=0.003), POD 21-27 (231.0±64.2,n= 21,p=0.0003 and on POD 28-41 time point (261.7±61.1,n=18,p=0.0005).

Conclusion: Plasma MMP-2 levels are significantly elevated from baseline for over 4 weeks after CRC MICR. The etiology of these changes in unclear, however, surgical trauma-associated inflammation may account for the early increase whereas tissue remodeling associated with wound healing likely accounts for the mid and late postop elevations. Increased MMP-2 levels may promote tumor growth in residual tumor deposits and formation of metastases. Further study is warranted.

23

Share this:

  • Twitter
  • Facebook
  • LinkedIn
  • Pinterest
  • WhatsApp
  • Reddit

Related

« Return to SAGES 2016 abstract archive

Our Mission

Innovate, educate and collaborate to improve patient care.

Recently, on SAGES…

Surgery is Safer with Vaccination 1

Addressing Religious Concerns About COVID-19 Vaccine

This may be a difficult subject matter for you and your patient to talk about.  Be assured, all major organized religious groups encourage and recommend the COVID-19 vaccine. Listed below are references and websites you can direct your patient towards to help them make an informed decision with regards to their religious concerns against the […]

SAGES Statement on AAPI Violence

The Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) stands in solidarity with the Asian American and Pacific Islander (AAPI) community. In the summer of 2020, SAGES released a statement condemning the violence, racism, and hatred toward the Black community in the wake of George Floyd and Breonna Taylor’s murders. It is with great sorrow […]

Free SAGES Webinar: Lessons from COVID on Living and Thriving as Surgeons

SAGES recognizes that the COVID-19 pandemic has had a big impact on surgical practice and in surgeon wellness. SAGES’ Reimagining the Practice of Surgery Taskforce will present “Finding the Opportunities: Lessons from COVID and How We Live and Thrive as Surgeons”  to look at ways in which innovative leadership at various levels may help transform […]

Contact SAGES

Society of American Gastrointestinal and Endoscopic Surgeons
11300 W. Olympic Blvd Suite 600
Los Angeles, CA 90064 USA
[email protected]
Tel: (310) 437-0544

Find Us Around the Web!

  • Facebook
  • Twitter
  • YouTube

Important Links

SAGES 2022 Meeting Information

Healthy Sooner: Patient Information

SAGES Guidelines, Statements, & Standards of Practice

SAGES Manuals

 

  • taTME Study Info
  • Foundation
  • SAGES.TV
  • MyCME
  • Educational Activities

Copyright © 2022 Society of American Gastrointestinal and Endoscopic Surgeons