Xiaoxing Chen, PhD1, Yadong Feng1, Jie Zhang2, Hong Zhu1, Shunfu Xu1, Wenfang Cheng1, Jinliang Ni1, Bin Xiao3. 1Department of Gastroenterology, First Affiliated Hospital with Nanjing Medical University, 2Department of Radiology, Xuzhou Central Hospital, 3Department of Pancreatic Centre, First Affiliated Hospital with Nanjing Medical University
Background: Dysfunction of the sphincter of Oddi (SO) may be involved in the etiology of common bile duct (CBD) stones. However, this possibility is controversial and needs further characterization.
Aims: This study was to evaluate SO motor activity in patients with CBD stones in the Han population of China.
Patients and methods: In this study, 76 patients with CBD stones were enrolled in a single tertiary endoscopy center. Data of SO motor activities was prospectively evaluated by endoscopic manometry. Mean basal SO pressure, amplitude and frequency were collected and analyzed.
Results: The mean basal SO pressure, amplitude, and frequency were 52.68±40.03 (1.60–171.1) mmHg, 39.93±19.67 (14.9–115.5) mmHg, and 5.73±3.20 (1.3–13.8)/min, respectively. The basal SO pressure was higher in patients with CBD stones < 10mm in diameter than in those with CBD stones with larger diameters. There was no significant difference in the basal SO pressure, amplitude, and frequency when compared with the CBD diameter, CBD stone number, prior cholecystectomy, periampullary diverticula, and symptoms. Levels of alanine aminotransferase, aspartate transaminase, γ-glutamyl transpeptidase, and alkalinephosphatase showed no significant difference in patients with normal or elevated basal SO pressures. Conclusion: These results identify abnormalities of SO motor activity that correlate with the formation of CBD stones.
Presented at the SAGES 2017 Annual Meeting in Houston, TX.
Abstract ID: 78587
Program Number: P103
Presentation Session: Poster (Non CME)
Presentation Type: Poster