Objective The aim was to find out if the ratio of lymph node would predict as a prognostic factor on the overall survival in the colon cancer (CC) stage III.
Method, out of 402 patient 198 with CC-stage III who were selected in accordance with the including criteria of the study were analysed from a prospectively maintained colorectal cancer database. The ratio of lymph node (RLN) was clarified as the number of metastatic lymph nodes divided by the total number of nodes removed. Comparison was made between the RLN, TNM nodal status and number of positive lymph nodes by the Kaplan-Meier method. An analysis of covariates was performed by a Cox proportional hazard regression analysis.
Results there was a significant difference in overall survival between patients classified by the RLN and pN stages in accordance to both uni and multivariate analysis. The lymph node ratio was the strongest covariate in the multivariate regression analysis for survival (p<0.0001).
Conclusion RLN can be considered a simple and reproductive modality to assess prognosis of patients underwent potentially curative surgery for lymph node positive colon cancer.
Program Number: P098