Fahad Alasfar, MD, FACS1, Ebaa Al Ozairi, MD2, Eman Al Shawaf, PhD3, Shaima Al Beloushi3, Hossein Arefanian, PhD3. 1Department of Surgery, Faculty of Medicine, Kuwait University, 2Department of Medicine, Faculty of Medicine, Kuwait University, 3Dasman Diabetes Institute, Kuwait
Introduction: Both morbid obesity and Type 2 Diabetes are a growing health problem in Kuwait and worldwide. Bariatric surgery considered one of the most effective options to treat morbid obesity .Laparoscopic Sleeve gastrectomy (LSG) emerges as a primary procedure to treat morbid obesity beside other procedure like Gastric Bypass. In this study, we look at the effect of LSG on Amylin and Glucose homeostasis on both morbid obese diabetic and non-diabetic patients.
Method: Between January 2012 and July 2014, 23 morbid obese and 17 morbid obese diabetic patients underwent LSG, with 19 lean diabetic and 15 lean subjects as control. Fasting blood Samples were collected for Glucose, insulin, Proinsulin, C-peptide, HbA1c and Amylin preoperatively and from control group then at 7, 15, 30, 60, 90,180 and 360 days postoperatively.
Results: Both morbid obese diabetic and non-diabetic patients were similar in preoperative BMI, gender, and age. EBWL after one year was 54% (41-73) in morbid obese diabetic and 73.15% (52-98) in morbid obese patients with no statistical difference. Fasting glucose, insulin, proinsulin, c- peptide, HOMA IR, and total amylin were significantly decreased after 360 days in both morbid obese and morbid obese diabetic patients.
Conclusion: LSG has a favorable effect in glucose homeostasis at one year after LSG in both morbid obese and morbid obese diabetic patients. Total Amylin was significantly decreased one year after LSG in both groups which may prevent the progression to B cell death.
Presented at the SAGES 2017 Annual Meeting in Houston, TX.
Abstract ID: 79331
Program Number: P561
Presentation Session: Poster (Non CME)
Presentation Type: Poster