Nano composite Based 3D printing of Magnetically Controlled Scaffolds for Cancer Therapy

Agila Shanmugam, Poornima Jayamani. Sri Ramakrishna Engineering College

Scaffolds are salient materials used in tissue engineering. Nanocomposite scaffolds act as potential drug carriers in the treatment of a variety of cancer. 3D printing allows scaffolds to be contrived with custom design thus eliminating the risks of suitable pore size for bioactivity and custom designing. This paper projects the potentiality of producing 3D printed nanostructured scaffolds using graphene oxide and polymer nanocomposite (Poly-Caprolactone) that could deliver drugs to cancer cells, effectively reducing neovascularizations. We present an effective technique for remotely controlling the scaffold by magnetic field to deliver the drugs to specific cancer sites. Nanostructured graphene polymer composite act as reinforcing agents to fabricate mechanically strong biodegradable scaffolds that could carry drugs to targeted cancer cells. Graphene has the ability to improve the biological properties and its ability to promote adhesion, proliferation proves it to be an effective material for scaffold designing. 3D Printing is useful for the direct fabrication of scaffolds with tailored porosity from a CAD file. The 3D-Bioplotter System is a suitable 3D Bioprinter for scaffold fabrication. Graphic Software such as NetFab, supplied with the device, would allow easy transfer of 3D model from CAD applications to G code. G code is recorded on an SD card and the device reads the data and then creates a model of the scaffold in a relatively short time depending on its complexity.

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