Impact of Transoral Incisionless Fundoplication Fasteners on Lower Esophageal Sphincter Anatomy & Physiology: A Balancing Act

INTRODUCTION: Transoral incisionless fundoplication (TIF) may have improved outcomes over simple, single shot, endoscopic therapy because it allows the surgeon to tailor the fundoplication to the gastro-esophageal (GE) anatomy by placing transmural fastener sets in critical GE locations. How each successive fastener set impacts LES valve anatomy and physiology is unknown. METHODS & PROCEDURES: While under general anesthesia dogs (N=3) underwent EGD to evaluate GE anatomy, and vector volume analysis and manometry were used to evaluate LES structure and physiology before & after endoscopic and sequential placement of 4 sets of ‘H’ fasteners in specific anatomic locations near the GE junction. Data is presented as mean ± SEM. Comparisons were made using Paired t-test or ANOVA with repeated measures and significance was assigned (P

Session: Poster

Program Number: P204

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