Hormonal Evaluation Following the Laparoscopic Treatment of Type 2 Diabetes Mellitus Patients with Bmi 20 – 34

Introduction: A group of patients with Type 2 Diabetes (T2DM) and BMI 20-34 were submitted to the laparoscopic interposition of a segment of ileum into the proximal jejunum or into the proximal duodenum associated to a sleeve gastrectomy. The objective of this study is to evaluate the hormonal changes in the pre and postoperative period.
Methods: Hormonal evaluation was done in 58 patients operated between April 2005 and July 2006. Mean age was 51.4 years (40-66). Mean BMI was 28.2 (20–34.8). All patients had the diagnosis of T2DM for at least 3 years. Mean duration of T2DM was 9.6 years (3-22). Two techniques were performed, consisting in different combinations of Ileal interposition (II) associated to a sleeve gastrectomy (SG). The following hormones were assayed in the pre and postoperative period (mean of 16months) at the baseline and following specific food stimulation (30-60-120min): GLP-1, GIP, Insulin, Glucagon, C-pepide, Amylin, CCK, PPP, Somatostatin, PYY, Ghrelin, Adiponectin, Resistin, Leptin and IL-6.
Results: 30 patients had the II associated to a sleeve gastrectomy (II-SG) and 28 had an II with a diverted sleeve gastrectomy (II-DSG). GLP1 had an important rise following the 2 operations, especially after the II-DSG (p

Session: Podium Presentation

Program Number: S082

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