• Skip to main content
  • Skip to header right navigation
  • Skip to site footer

Log in
  • Search
    • Search All SAGES Content
    • Search SAGES Guidelines
    • Search the Video Library
    • Search the Image Library
    • Search the Abstracts Archive
www.sages.org

SAGES

Reimagining surgical care for a healthier world

  • Home
    • Search
    • SAGES Home
    • SAGES Foundation Home
  • About
    • Awards
    • Who Is SAGES?
    • Leadership
    • Our Mission
    • Advocacy
    • Committees
      • SAGES Board of Governors
      • Officers and Representatives of the Society
      • Committee Chairs and Co-Chairs
      • Committee Rosters
      • SAGES Past Presidents
  • Meetings
    • SAGES NBT Innovation Weekend
    • SAGES Annual Meeting
      • 2026 Scientific Session Call for Abstracts
      • 2026 Emerging Technology Call for Abstracts
    • CME Claim Form
    • SAGES Past, Present, Future, and Related Meeting Information
    • SAGES Related Meetings & Events Calendar
  • Join SAGES!
    • Membership Application
    • Membership Benefits
    • Membership Types
      • Requirements and Applications for Active Membership in SAGES
      • Requirements and Applications for Affiliate Membership in SAGES
      • Requirements and Applications for Associate Active Membership in SAGES
      • Requirements and Applications for Candidate Membership in SAGES
      • Requirements and Applications for International Membership in SAGES
      • Requirements for Medical Student Membership
    • Member Spotlight
    • Give the Gift of SAGES Membership
  • Patients
    • Join the SAGES Patient Partner Network (PPN)
    • Patient Information Brochures
    • Healthy Sooner – Patient Information for Minimally Invasive Surgery
    • Choosing Wisely – An Initiative of the ABIM Foundation
    • All in the Recovery: Colorectal Cancer Alliance
    • Find A SAGES Surgeon
  • Publications
    • Sustainability in Surgical Practice
    • SAGES Stories Podcast
    • Patient Information Brochures
    • Patient Information From SAGES
    • TAVAC – Technology and Value Assessments
    • Surgical Endoscopy and Other Journal Information
    • SAGES Manuals
    • MesSAGES – The SAGES Newsletter
    • COVID-19 Archive
    • Troubleshooting Guides
  • Education
    • Wellness Resources – You Are Not Alone
    • Avoid Opiates After Surgery
    • SAGES Subscription Catalog
    • SAGES TV: Home of SAGES Surgical Videos
    • The SAGES Safe Cholecystectomy Program
    • Masters Program
    • Resident and Fellow Opportunities
      • MIS Fellows Course
      • SAGES Robotics Residents and Fellows Courses
      • SAGES Free Resident Webinar Series
      • Fluorescence-Guided Surgery Course for Fellows
      • Fellows’ Career Development Course
    • SAGES S.M.A.R.T. Enhanced Recovery Program
    • SAGES @ Cine-Med Products
      • SAGES Top 21 Minimally Invasive Procedures Every Practicing Surgeon Should Know
      • SAGES Pearls Step-by-Step
      • SAGES Flexible Endoscopy 101
    • SAGES OR SAFETY Video Activity
  • Opportunities
    • Fellowship Recognition Opportunities
    • SAGES Advanced Flexible Endoscopy Area of Concentrated Training (ACT) SEAL
    • Multi-Society Foregut Fellowship Certification
    • Research Opportunities
    • FLS
    • FES
    • FUSE
    • Jobs Board
    • SAGES Go Global: Global Affairs and Humanitarian Efforts
  • OWLS/FLS
You are here: Home / Abstracts / Obesity and Non-Alcoholic Fatty Liver Disease: Cause and Effect?

Obesity and Non-Alcoholic Fatty Liver Disease: Cause and Effect?

Khaleel Mohammad, MD1, Marcoandrea Giorgi, MD1, Jawad Ali, MD1, Rouzbeh Moustaedi, MD2, Aaron Carr, MD1, Mohamed Ali, MD1. 1UC Davis Medical Center, 2The Permanente Medical Group

Introduction: Obesity has been commonly cited to be a major risk factor for the occurrence and progression of non-alcoholic fatty liver disease (NAFLD). In particular, bariatric surgery patients are hypothesized to be at highest risk for NAFLD and its consequences.  In this study, we sought to characterize the extent of NAFLD, the prevalence of progression to NASH and fibrosis, and identify patient characteristics that correlate with fatty liver disease in this high-risk population.

Methods: Core liver biopsy was obtained on 529 consecutive patients undergoing bariatric surgery and assessed for the degree of steatosis, portal inflammation, and hepatic fibrosis.  Demographic, anthropometric, laboratory, and co-morbidity data were collected and analyzed to identify relationships between the clinical condition of the patient and NAFLD.

Results: The study included 529 patients with an average body mass index (BMI) and age of 45.3±7.5 kg/m2and 45.3±11.2 years, respectively.  Metabolic syndrome was present in 71.8% of patients.  Hepatic steatosis, NASH and fibrosis were present in 69.6%, 44.2% and 18.1% of patients, respectively.  There was a significant direct correlation between degree of steatosis and preoperative BMI (p<0.05), serum triglycerides (p<0.0001), and hemoglobin A1C (HbA1C) (p<0.0001), while HDL showed an inverse correlation with the degree of hepatic steatosis (p<0.001). Patients with metabolic syndrome had more steatosis (p <0.0001) and steatohepatitis (p<0.005) than patients without metabolic syndrome.

Conclusions: Factors such as elevated BMI, triglycerides, HbA1C and presence of metabolic syndrome correlated with the degree of hepatic steatosis.  Although the majority of patients in this study exhibited hepatic steatosis, 30.4% of patients did not have steatosis despite having the high risk traditionally ascribed to advanced obesity. These findings suggest that the mere presence of obesity may not be enough to promote the progression of NAFLD to NASH and fibrosis and indicate that metabolic dysregulation may play a more vital role.


Presented at the SAGES 2017 Annual Meeting in Houston, TX.

Abstract ID: 95869

Program Number: P101

Presentation Session: Poster Session (Non CME)

Presentation Type: Poster

View this Poster

44

Share this:

  • Click to share on X (Opens in new window) X
  • Click to share on Facebook (Opens in new window) Facebook
  • Click to share on LinkedIn (Opens in new window) LinkedIn
  • Click to share on Pinterest (Opens in new window) Pinterest
  • Click to share on WhatsApp (Opens in new window) WhatsApp
  • Click to share on Reddit (Opens in new window) Reddit
  • Click to share on Pocket (Opens in new window) Pocket
  • Click to share on Mastodon (Opens in new window) Mastodon
  • Click to share on Threads (Opens in new window) Threads
  • Click to share on Bluesky (Opens in new window) Bluesky

Related


sages_adbutler_leaderboard

Hours & Info

11300 West Olympic Blvd, Suite 600
Los Angeles, CA 90064

1-310-437-0544

[email protected]

Monday – Friday
8am to 5pm Pacific Time

Find Us Around the Web!

  • Bluesky
  • X
  • Instagram
  • Facebook
  • YouTube

Copyright © 2025 · SAGES · All Rights Reserved

Important Links

Healthy Sooner: Patient Information

SAGES Guidelines, Statements, & Standards of Practice

SAGES Manuals