Liver Resection for Hepatocellular Carcinoma: Case-Matched Analysis of Laparoscopic Versus Open Resection

Yang Seok Koh, MD, Ho Hyun Kim, MD, Eun Kyu Park, MD, Jin Shick Seoung, MD, Young Hoe Hur, MD, Jung Chul Kim, MD, Chol Kyoon Cho, MD, Hyun Jong Kim, MD. Department of Surgery, Chonnam National University Medical School

Purpose: This study aimed to analyze the outcomes of laparoscopic liver resection compared with open liver resection for hepatocellular carcinoma (HCC).
Methods: Between July 2005 and December 2009, Twenty-six consecutive patients with HCC were underwent pure laparoscopic liver resection, and data of this group (laparoscopic liver resection group, L-group) were compared to a retrospective control group of 29 patients who underwent open liver resection for HCC (open liver resection group, O-group) during the same period. All of 55 patients were underwent surgical resection by single surgeon. The two groups were matched in terms of demographic data, tumor size, degree of liver cirrhosis, American Society of Anesthesiology (ASA) score, type of resection and tumor location.
Results: In L-group, median operation time and the amount of intraoperative packed RBC transfusion were 147.5 minutes and 0.35 unit, respectively. L-group resulted in shorter operation time (147.5 minutes vs 220.0 minutes, P = 0.031). There were no difference in perioperative morbidity and mortality rate (3.8%, 0% vs 24.1%, 0%; P = 0.054, NS respectively); L-group was associated a shorter hospital stay than O-group (11.08 days vs 16.07 days, P = 0.034). After a mean follow up of 23.9 months (range 0.7-59.4 months), 1-year disease free survival rate was 84.6% for L-group, 82.8% for O-group (P = 0.673).
Conclusion: Laparoscopic liver resection of HCC is feasible and safe in selected patients and can result in good surgical results and shorter postoperative hospital stay with similar outcomes in terms of perioperative morbidity, mortality, and disease-free survival.

Session: Poster
Program Number: P386
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