Berta Gonzalo, Carlos Rodríguez-Otero, Meritxell Garay, Mercedes Camacho, Sonia Fernández, Inka Miñambres, Irene Gómez, Eulàlia Ballester, Carmen Balagué. Hospital Sant Pau
Background amb Aims: Laparoscopic vertical gastrectomy (LSG) is a growing technique in recent decades for the treatment of obesity. There are different theories about the influence of LSG on the hormones involved in glycolipid metabolism. The aim of this study is to analyze the influence of this technique on the levels of GIP, GLP-1, glucagon, ghrelin, insulin, leptin and PYY and the presence of differences according to the two bougie sizes used for gastrectomy.
Material and Methods: Prospective randomized study (Protocol IIBSP-RES-2012-178, EAES Research Project) that included patients undergoing vertical gastrectomy randomized into 4 groups according to distance to the pylorus at the beginning of gastrectomy (2 vs 5cm) and size of the probe used for the gastrectomy (bougie size, 33 vs 42 Fr). A total of 33 patients (24 women and 9 men) who had completed the complete follow-up one year after the intervention were analyzed. The blood values ??of GIP, GLP-1, glucagon, ghrelin, insulin, leptin and PYY were determined preoperatively, postoperatively immediately (48h post IQ), 2 months and 1 year postoperatively.
Results: The average decrease of the hormones studied, at in the immediate postoperative period, at 2 months and a year after sleeve gastrectomy were (pg/ml): GIP 48.65 ± 10.09/ 33.15 ±11.97/ 37.84 ±10.45, GLP-1 6.29 ±6.85 (p=0.36)/ 13.01 ±5.07/ 17.71 ±8.03, glucagon -13.73 ±7.28 (p=0.06)/ 15.06 ±6.14/ 21.78 ±5.68, ghrelin 33.55 ±6.73/ 30.36 ±7.02/ 32.49 ±6.76, Insulin 209.56 ±108.98 (p=0.06)/ 704.13 ±124.32/ 788.91 ±97.76, Leptin -6964.24 ±4757.32 (p=0.15)/ 24143.03 ±4744.26/ 24192.67 ±5368.06 and PYY 14.51 ±20.08 (p=0.47)/ 8.19 ±12.79 (p=0.53)/ 1.29 ±9.65 (p=0.89). All results were statistically significant excepte those specified with the value of p.
Conclusion: Laparoscopic vertical gastrectomy has significant effects on the hormones involved in obesity, mainly at two months and one year after surgery. The size of the bougie is not an influential factor in the observed hormonal response.
Presented at the SAGES 2017 Annual Meeting in Houston, TX.
Abstract ID: 95464
Program Number: P115
Presentation Session: Poster Session (Non CME)
Presentation Type: Poster