Nesidioblatosis

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Shawn Tsuda
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Nesidioblastosis refers to pancreatic islet cell proliferation.  This occurs during normal neonatal development.  It can occur pathological in infants, causing hyperinsulinism and hypoglycemia.

Nesidioblastosis after Gastric Bypass

Following a Roux-en-Y gastric bypass, hyperinsulinism and hypoglycemia may result from beta cell hyperproliferation, or nesidioblastosis.  While this may be due to an unmasked, subclinical congenital hypoglycemia, there is some evidence that glucagon-like peptide 1 (GLP-1) may be implicated in the pathophysiology.

 

References

  1. Goldfine AB, Mun EC, Devine E, Bernier R, Baz-Hecht M, Jones DB, Schneider BE, Holst JJ, Patti ME.

     J Clin Endocrinol Metab. 2007 Dec;92(12):4678-85.