Nesidioblatosis

First submitted by:
Shawn Tsuda
(see History tab for revisions)
Category

Nesidioblastosis refers to pancreatic islet cell proliferation.  This occurs during normal neonatal development.  It can occur pathological in infants, causing hyperinsulinism and hypoglycemia.

Nesidioblastosis after Gastric Bypass

Following a Roux-en-Y gastric bypass, hyperinsulinism and hypoglycemia may result from beta cell hyperproliferation, or nesidioblastosis.  While this may be due to an unmasked, subclinical congenital hypoglycemia, there is some evidence that glucagon-like peptide 1 (GLP-1) may be implicated in the pathophysiology.

 

References

  1. Goldfine AB, Mun EC, Devine E, Bernier R, Baz-Hecht M, Jones DB, Schneider BE, Holst JJ, Patti ME.

     J Clin Endocrinol Metab. 2007 Dec;92(12):4678-85.