• Skip to main content
  • Skip to header right navigation
  • Skip to site footer

Log in
  • Search
    • Search All SAGES Content
    • Search SAGES Guidelines
    • Search the Video Library
    • Search the Image Library
    • Search the Abstracts Archive
www.sages.org

SAGES

Reimagining surgical care for a healthier world

  • Home
    • Search
    • SAGES Home
    • SAGES Foundation Home
  • About
    • Awards
    • Who Is SAGES?
    • Leadership
    • Our Mission
    • Advocacy
    • Committees
      • SAGES Board of Governors
      • Officers and Representatives of the Society
      • Committee Chairs and Co-Chairs
      • Committee Rosters
      • SAGES Past Presidents
  • Meetings
    • SAGES NBT Innovation Weekend
    • SAGES Annual Meeting
      • 2026 Scientific Session Call for Abstracts
      • 2026 Emerging Technology Call for Abstracts
    • CME Claim Form
    • SAGES Past, Present, Future, and Related Meeting Information
    • SAGES Related Meetings & Events Calendar
  • Join SAGES!
    • Membership Application
    • Membership Benefits
    • Membership Types
      • Requirements and Applications for Active Membership in SAGES
      • Requirements and Applications for Affiliate Membership in SAGES
      • Requirements and Applications for Associate Active Membership in SAGES
      • Requirements and Applications for Candidate Membership in SAGES
      • Requirements and Applications for International Membership in SAGES
      • Requirements for Medical Student Membership
    • Member Spotlight
    • Give the Gift of SAGES Membership
  • Patients
    • Join the SAGES Patient Partner Network (PPN)
    • Patient Information Brochures
    • Healthy Sooner – Patient Information for Minimally Invasive Surgery
    • Choosing Wisely – An Initiative of the ABIM Foundation
    • All in the Recovery: Colorectal Cancer Alliance
    • Find A SAGES Surgeon
  • Publications
    • Sustainability in Surgical Practice
    • SAGES Stories Podcast
    • Patient Information Brochures
    • Patient Information From SAGES
    • TAVAC – Technology and Value Assessments
    • Surgical Endoscopy and Other Journal Information
    • SAGES Manuals
    • MesSAGES – The SAGES Newsletter
    • COVID-19 Archive
    • Troubleshooting Guides
  • Education
    • Wellness Resources – You Are Not Alone
    • Avoid Opiates After Surgery
    • SAGES Subscription Catalog
    • SAGES TV: Home of SAGES Surgical Videos
    • The SAGES Safe Cholecystectomy Program
    • Masters Program
    • Resident and Fellow Opportunities
      • MIS Fellows Course
      • SAGES Robotics Residents and Fellows Courses
      • SAGES Free Resident Webinar Series
      • Fluorescence-Guided Surgery Course for Fellows
      • Fellows’ Career Development Course
    • SAGES S.M.A.R.T. Enhanced Recovery Program
    • SAGES @ Cine-Med Products
      • SAGES Top 21 Minimally Invasive Procedures Every Practicing Surgeon Should Know
      • SAGES Pearls Step-by-Step
      • SAGES Flexible Endoscopy 101
    • SAGES OR SAFETY Video Activity
  • Opportunities
    • Fellowship Recognition Opportunities
    • SAGES Advanced Flexible Endoscopy Area of Concentrated Training (ACT) SEAL
    • Multi-Society Foregut Fellowship Certification
    • Research Opportunities
    • FLS
    • FES
    • FUSE
    • Jobs Board
    • SAGES Go Global: Global Affairs and Humanitarian Efforts
  • OWLS/FLS
You are here: Home / Abstracts / The Systemic Effect and The Absorption Rate of Aerosolized Intra-peritoneal Heparin With or Without Hyaluronic Acid in the Prevention of Postoperative Abdominal Adhesion

The Systemic Effect and The Absorption Rate of Aerosolized Intra-peritoneal Heparin With or Without Hyaluronic Acid in the Prevention of Postoperative Abdominal Adhesion

Ahmed Almamar, MD, MSc, FRCSC, Nawar Alkhamesi, MD, PhD, FRCS, FRCSED, FRCSC, Christopher M Schlachta, BSc, MDCM, FRCSC, FACS. Western University and Canadian Surgical Technologies and Advanced Robotics (CSTAR), London, Canada

Introduction: Adhesions are a cause of morbidity following surgery. Multiple approaches have been evaluated to minimize them. Aerosolized heparin and hyaluronic acid is an effective method to prevent adhesions whether they were used independently or in synergism. However, the absorption rate of aerosolized intraperitoneal heparin alone or mixed with hyaluronic acid and its systemic effect never been evaluated. The aim was to evaluate the systemic effect and the absorption rate of heparin with or without hyaluronic acid in the prevention of abdominal adhesion.

Material and Methods: A randomized-controlled study was conducted comparing thirty rats divided into 3 groups. First group (n=10) received aerosolized intra-peritoneal heparin (IPH). Second group (n=10) received intra-peritoneal heparin mixed with hyaluronic acid (IPHHA). Intravenous heparin (IVH) was given to the third group (n=10) (Positive control). Serum heparin levels for each animal were measured and compared between the groups over at 30, 60, 90, and120 minute’s period.

Results: None of the rats had intra-operative bleeding. Serum heparin in the aerosolized groups (IPH & IPHHA) were significantly lower than the control group (IVH) at all points of measurements with IPHHA showing the lowest absorption compared to IPH & IVH (p<0.0001). The serum level of heparin of all groups peaked at 90 minutes. Area-under-the-curve 0-120 was significantly lower in the IPHHA group as compared to both IPH and IVH (p<0.0001).

Conclusion: The aerosolized intra-peritoneal heparin alone or in combination with hyaluronic acid resulted in minimal systemic absorption rendering it safe for the use as method to prevent adhesions. Human studies are planed.


Presented at the SAGES 2017 Annual Meeting in Houston, TX.

Abstract ID: 78777

Program Number: P077

Presentation Session: Poster (Non CME)

Presentation Type: Poster

41

Share this:

  • Click to share on X (Opens in new window) X
  • Click to share on Facebook (Opens in new window) Facebook
  • Click to share on LinkedIn (Opens in new window) LinkedIn
  • Click to share on Pinterest (Opens in new window) Pinterest
  • Click to share on WhatsApp (Opens in new window) WhatsApp
  • Click to share on Reddit (Opens in new window) Reddit
  • Click to share on Pocket (Opens in new window) Pocket
  • Click to share on Mastodon (Opens in new window) Mastodon
  • Click to share on Threads (Opens in new window) Threads
  • Click to share on Bluesky (Opens in new window) Bluesky

Related


sages_adbutler_leaderboard

Hours & Info

11300 West Olympic Blvd, Suite 600
Los Angeles, CA 90064

1-310-437-0544

[email protected]

Monday – Friday
8am to 5pm Pacific Time

Find Us Around the Web!

  • Bluesky
  • X
  • Instagram
  • Facebook
  • YouTube

Copyright © 2025 · SAGES · All Rights Reserved

Important Links

Healthy Sooner: Patient Information

SAGES Guidelines, Statements, & Standards of Practice

SAGES Manuals