Muhammad Abbas, Dr1, Muhammad Naveed, Dr1, Murad Habib, Dr2, Kuldeep Dhama, Dr3, Meiqi Shi, Surgeon4, Chen Dingding, Prof1. 1Department Of Clinical Pharmacy, School Of Basic Medicines And Clinical Pharmacy, China Pharmaceutical University Nanjing 211198, China, 2Department Of Pediatrics, Women And Children Hospital Abbottabad 22044, Pakistan, 3Division of Pathology, ICAR- Indian Veterinary Research Institute, Izatnagar, 243122 Bareilly, India, 4Department Of Medical Oncology, Jiangsu Cancer Hospital Nanjing 211198, China
Gastric stomach cancer is a rapid major cause of cancer-related death globally, have higher incidence in men and it is noticeable by its heterogeneity. A lot of studies have expressed out the molecular basis of this cancer, include pathogenesis, invasion and metastasis. The invention of new technologies has help to bring out several novel biomarkers that have diagnostic and prognostic value. Therefore, this review centers on biomarkers for the early diagnosis, treatment and prognosis of gastric cancer, elaborate the clinical important of serum tumor markers in a patient with this cancer as well as checking the growths, prognosis together with epigenetic changes and genetic polymorphisms.
A deep and rigorous search was carried out in Pub Med/MEDLINE using specific words; “gastric cancer”, with “tumor marker”. Our search yielded 4947 important reports about related topic from books and articles that were published before the end of September 2016.
Conclusively, Scientists are utilizing time and resource to salvage this nemesis which is of global burden. Classical and Novel biomarkers are important for treatment as well as pre-post diagnosis of GC. Major causes for this disease are cigarette smoking, infection by helicobacter pylori, atrophic gastritis, male sex, and high salt intake. The treatment of which early diagnoses is of important to the management, after pathological diagnoses by stage prognosis and metastatic setting, although the outcome proved not so good includes chemotherapy, and oral medication are oxaliplatin, capecitabine, cisplatin and 5- fluorouracil (5-FU).
Key words: Stomach cancer, Gastric tumor markers, Pre and post chemotherapy, Diagnosis, Prognosis, Treatment
Significance Statement: Early discovery of Biomarkers is necessary for treatment and management of Gastric cancer, and help to quantify GC state. Stomach Cancer has divested the health of many people, and millions has died from this epidemic. Chemotherapy is the possible form of treatment for cancer. Prognosis relies on pathological and histological studies. Thus compilations of information about biomarkers are necessary for clinician in decision making.
Presented at the SAGES 2017 Annual Meeting in Houston, TX.
Abstract ID: 84996
Program Number: P752
Presentation Session: iPoster Session (Non CME)
Presentation Type: Poster