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SIK1 Expression is Down-regulated in Colorectal Cancer and Implies Poor Clinical Outcome

Chengzhi Huang. Guangdong General Hospital (Guangdong Academy of Medical Science)

Keywords: SIK1, Colorectal cancer, Prognosis, Tumor biomarker.

Background: Colorectal cancer (CRC) is one of the most common malignant diseases over the world. Of the causes of the death of CRC, metastasis to liver or lung are the major factors. However, there is still lack of precise tumor biomarker that precisely predict the clinical outcome of CRC. The salt-inducible kinase 1 (SIK1) encodes a serine kinase of AMP-activated protein kinase(AMPK) family, which may play critical roles in tumorigenesis and tumor progression. This study aimed the study the expression and clinical significance of SIK1 and CRC patients.

Methods: The expression of SIK1 protein was measured by western-blot and analysis of immunohistochemistry. SIK1 mRNA expression in cancerous tissue was measured by RT-PCR.

Results: The expression level of SIK1 was correlated with the following factors: tumor invasion (T stages), lymph node metastasis, clinical stages(TNM) and tumor location. The down-regulated SIK1 implies poor clinical outcome measured by Kaplan-Meier analysis (P-value<0.05), and may act as an independent risk factor of CRC patients.

Conclusions: The protein SIK1 is down-regulated in CRC cancer tissues, and may implies poor clinical outcome.


Presented at the SAGES 2017 Annual Meeting in Houston, TX.

Abstract ID: 86163

Program Number: P259

Presentation Session: iPoster Session (Non CME)

Presentation Type: Poster

39

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