Minimally invasive colon resection is associated with increased sVEGFR1 and decreased sVEGFR2 plasma levels early after surgery; the net impact is decreased binding of free VEGF which may account for increased plasma VEGF levels early post surgery

Introduction: Plasma VEGF levels are increased after minimally invasive colorectal resection (MICR) for both benign and malignant disease. VEGF, which is critical to both wound healing and tumor growth, induces angiogenesis by binding to endothelial cell bound VEGF-Receptor 1 (VEGFR1) and VEGF-Receptor 2 (VEGFR2). Soluble VEGF-Receptor-1 (sVEGFR1) and soluble VEGF-Receptor-2 (sVEGFR2), which are not capable of signal transduction, bind VEGF in the bloodstream and decrease the levels of free VEGF in the plasma, thus, decreasing VEGF’s proangiogenic effect. To better understand the etiology of the surgery-related VEGF increase it is necessary to determine surgery’s effect on sVEGFR1 and sVEGFR2. The purpose of this study was to assess the plasma levels of these 2 proteins after MICR for non-malignant indications.
Methods: Blood samples were obtained preoperatively (preop) and on postoperative day (POD) 1 and 3 in patients undergoing MICR for benign indications (n=24). In 8 patients a 4th specimen was obtained between POD 7 and 13. sVEGFR1 and sVEGFR2 levels were determined via ELISA. The mean and SD were determined for each parameter and time point. The POD 7-13 specimens were bundled and considered as one time point. t-test was used for the analysis and inverse transformation was performed to transform sVEGFR1data to normal distribution. (Significance level p

Session: Podium Presentation

Program Number: S014

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