Chumpon Wilasrusmee, MD, MSc1, Boonying Siribumrungwong2, Napaphat Poprom, BSc1. 1Faculty of Medicine Ramathibodi Hospital, Mahidol University, 2Department of Surgery, Faculty of Medicine, Thammasat University Hospital
Background: MPV, CBC-parameter, is potential biomarker of platelet activity in cancer and VTE. However, recent CATS-study showed that high-MPV levels associated with a decreased VTE risk.
Aim-To investigate the role of MPV in VTE and colorectal-cancer.
Methods: A retrospective study was performed to analyze differences of MPV between patients with VTE, VTE and colorectal-cancer, and control.
Two reviewers independently extracted data for meta-analysis. Differences in MPV were expressed as unstandardized mean difference
Results: Among 170 patients, 58-control, 54-VTE, and 58-VTE with colorectal-cancer, MPV was significantly higher in VTE groups(table1).
From 403 articles, 10 studies(5 cohorts and 5 case-controls) comprising 2,265 patients. MPV was significantly higher in those with VTE (mean difference 0.61 fL,95%CI 0.34-0.88,P< 0.001). Elevated MPV increased the relative risk of VTE (RR 1.319,1.061-1.641,I2=82.5%)(figure1).
Conclusions: Our evidence suggests that elevated MPV is associated with VTE and VTE with colorectal-cancer. A mechanistic study and RCT are required in order to use antiplatelet therapy.
Presented at the SAGES 2017 Annual Meeting in Houston, TX.
Abstract ID: 80884
Program Number: P231
Presentation Session: Poster (Non CME)
Presentation Type: Poster