High Visceral Adipose Volume Impairs Beta-cell Function and May Influence Surgical Options

BACKGROUND: The mechanism for type-2 diabetes (T2DM) resolution following bariatric surgery is unknown, but is typically more robust for malabsorptive procedures (roux-en-Y gastric bypass, RYGB) than for restrictive procedures (laparoscopic gastric banding, LGB). We hypothesize that high visceral volume is a predictor of pre- or frank diabetes and surgeries that rapidly deplete visceral adipose stores more readily reverses T2DM.

METHOD: 37 female patients were admitted to the Clinical Research Center for evaluation prior to undergoing RYGB. A smaller cohort of patients underwent LGB. Visceral adipose tissue (VAT) volume was measured by waist circumference and standardized CT scan protocol. Beta-cell function (insulin secretion and disposition index) were evaluated by IVGTT. All patients were followed for 2 years. Correlations were performed with linear and multivariate analysis.

RESULTS: Patients with impaired fasting glucose or T2DM had the highest VAT volume compared with those with normal fasting glucose (5000 cc vs. 3100 cc, respectively p

Session: Podium Presentation

Program Number: S011

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