• Skip to main content
  • Skip to header right navigation
  • Skip to site footer

Log in
  • Search
    • Search All SAGES Content
    • Search SAGES Guidelines
    • Search the Video Library
    • Search the Image Library
    • Search the Abstracts Archive
www.sages.org

SAGES

Reimagining surgical care for a healthier world

  • Home
    • Search
    • SAGES Home
    • SAGES Foundation Home
  • About
    • Awards
    • Who Is SAGES?
    • Leadership
    • Our Mission
    • Advocacy
    • Committees
      • SAGES Board of Governors
      • Officers and Representatives of the Society
      • Committee Chairs and Co-Chairs
      • Committee Rosters
      • SAGES Past Presidents
  • Meetings
    • SAGES NBT Innovation Weekend
    • SAGES Annual Meeting
      • 2026 Scientific Session Call for Abstracts
      • 2026 Emerging Technology Call for Abstracts
    • CME Claim Form
    • SAGES Past, Present, Future, and Related Meeting Information
    • SAGES Related Meetings & Events Calendar
  • Join SAGES!
    • Membership Application
    • Membership Benefits
    • Membership Types
      • Requirements and Applications for Active Membership in SAGES
      • Requirements and Applications for Affiliate Membership in SAGES
      • Requirements and Applications for Associate Active Membership in SAGES
      • Requirements and Applications for Candidate Membership in SAGES
      • Requirements and Applications for International Membership in SAGES
      • Requirements for Medical Student Membership
    • Member Spotlight
    • Give the Gift of SAGES Membership
  • Patients
    • Join the SAGES Patient Partner Network (PPN)
    • Patient Information Brochures
    • Healthy Sooner – Patient Information for Minimally Invasive Surgery
    • Choosing Wisely – An Initiative of the ABIM Foundation
    • All in the Recovery: Colorectal Cancer Alliance
    • Find A SAGES Surgeon
  • Publications
    • Clinical / Practice / Training Guidelines, Statements, and Standards of Practice
    • Sustainability in Surgical Practice
    • SAGES Stories Podcast
    • Patient Information Brochures
    • Patient Information From SAGES
    • TAVAC – Technology and Value Assessments
    • Surgical Endoscopy and Other Journal Information
    • SAGES Manuals
    • MesSAGES – The SAGES Newsletter
    • COVID-19 Archive
    • Troubleshooting Guides
  • Education
    • Wellness Resources – You Are Not Alone
    • Avoid Opiates After Surgery
    • SAGES Subscription Catalog
    • SAGES TV: Home of SAGES Surgical Videos
    • The SAGES Safe Cholecystectomy Program
    • Masters Program
    • Resident and Fellow Opportunities
      • MIS Fellows Course
      • SAGES Robotics Residents and Fellows Courses
      • SAGES Free Resident Webinar Series
      • Fluorescence-Guided Surgery Course for Fellows
      • Fellows’ Career Development Course
    • SAGES S.M.A.R.T. Enhanced Recovery Program
    • SAGES @ Cine-Med Products
      • SAGES Top 21 Minimally Invasive Procedures Every Practicing Surgeon Should Know
      • SAGES Pearls Step-by-Step
      • SAGES Flexible Endoscopy 101
    • SAGES OR SAFETY Video Activity
  • Opportunities
    • Fellowship Recognition Opportunities
    • SAGES Advanced Flexible Endoscopy Area of Concentrated Training (ACT) SEAL
    • Multi-Society Foregut Fellowship Certification
    • Research Opportunities
    • FLS
    • FES
    • FUSE
    • Jobs Board
    • SAGES Go Global: Global Affairs and Humanitarian Efforts
  • OWLS/FLS
You are here: Home / Abstracts / Gip Gene Expression After Bariatric Surgery

Gip Gene Expression After Bariatric Surgery

Erin Moran-Atkin, MD, Fred Brody, MD MBA, Sidney Fu, MD PhD. The George Washington University Medical Center

Introduction: Following bariatric surgery, type 2 diabetes (T2D) may resolve quickly and correlates closely with incretin serum levels. One of these incretins, gastric inhibitory polypeptide (GIP), is produced in the duodenum and jejunum and increases following bariatric surgery; especially after Roux-en-Y gastric bypass (RYGB). This study analyzes GIP gene expression following bariatric surgery in order to clarify the potential pathophysiology between incretins and the resolution of T2D.

Method: The study includes 14 morbidly obese patients (9T2D and 5 non diabetic) that underwent bariatric surgery including gastric banding and RYGB. Nine patients (5 T2D; 4 non diabetic) underwent a gastric band and 5 patients (4 T2D; 1 non diabetic) underwent a RYGB. Preoperative blood was drawn the day of surgery and postoperative samples were collected at approximately three months. All blood samples were collected in PAXgene tubes to stabilize mRNA expression. Total RNA was extracted and purified, then cDNA was synthesized. Finally, real time quantitative PCR was used to quantify gene expression. Results were analyzed using Student’s t-test with a p<0.05 significant.

Results: At three months postoperatively, T2D completely resolved or significantly improved in 7 T2D (77.8%) patients. Four patients (2 RYGB and 2 gastric band) had discontinued all subcutaneous or oral medications. Three patients (2 RYGB and 1 gastric band) had discontinued subcutaneous insulin but remained on reduced levels of oral hypoglycemic agents. The remaining 2 T2D (22.2%) patients did not show any resolution of diabetes at 3 months postoperatively. Both of these patients underwent a gastric band. Postoperative GIP gene expression for all bariatric patients decreased 1.2 (p= 0.06) fold. However, the diabetic RYGB patients showed a 0.5 (p=0.38) fold increase in gene expression versus a 1.9 (p=0.08) fold decrease for gastric band patients.

Conclusion: This study represents one of the first analyses of GIP gene expression as opposed to serum levels following bariatric surgery. Although results are not statistically significant, the trend in gene expression on diabetic patients after RYGB seams to indicate that the resolution of DM in this group may be closely related to the incretin GIP. The anatomical differences secondary to a RYGB may account for the differences in gene expression versus a gastric band. Of note, patient accrual continues in order to discern the postoperative gene expression for GIP in a larger cohort. Regardless, this study begins to unravel the genomic elements that may comprise the foregut hypothesis regarding resolution of T2D.


Session: Poster
Program Number: P101
View Poster

117

Share this:

  • Click to share on X (Opens in new window) X
  • Click to share on Facebook (Opens in new window) Facebook
  • Click to share on LinkedIn (Opens in new window) LinkedIn
  • Click to share on Pinterest (Opens in new window) Pinterest
  • Click to share on WhatsApp (Opens in new window) WhatsApp
  • Click to share on Reddit (Opens in new window) Reddit
  • Click to share on Pocket (Opens in new window) Pocket
  • Click to share on Mastodon (Opens in new window) Mastodon
  • Click to share on Threads (Opens in new window) Threads
  • Click to share on Bluesky (Opens in new window) Bluesky

Related


sages_adbutler_leaderboard

Hours & Info

11300 West Olympic Blvd, Suite 600
Los Angeles, CA 90064

1-310-437-0544

[email protected]

Monday – Friday
8am to 5pm Pacific Time

Find Us Around the Web!

  • Bluesky
  • X
  • Instagram
  • Facebook
  • YouTube

Copyright © 2025 · SAGES · All Rights Reserved

Important Links

Healthy Sooner: Patient Information

SAGES Guidelines, Statements, & Standards of Practice

SAGES Manuals