• Skip to main content
  • Skip to header right navigation
  • Skip to site footer

Log in
  • Search
    • Search All SAGES Content
    • Search SAGES Guidelines
    • Search the Video Library
    • Search the Image Library
    • Search the Abstracts Archive
www.sages.org

SAGES

Reimagining surgical care for a healthier world

  • Home
    • Search
    • SAGES Home
    • SAGES Foundation Home
  • About
    • Awards
    • Who Is SAGES?
    • Leadership
    • Our Mission
    • Advocacy
    • Committees
      • SAGES Board of Governors
      • Officers and Representatives of the Society
      • Committee Chairs and Co-Chairs
      • Committee Rosters
      • SAGES Past Presidents
  • Meetings
    • SAGES NBT Innovation Weekend
    • SAGES Annual Meeting
      • 2026 Scientific Session Call for Abstracts
      • 2026 Emerging Technology Call for Abstracts
    • CME Claim Form
    • SAGES Past, Present, Future, and Related Meeting Information
    • SAGES Related Meetings & Events Calendar
  • Join SAGES!
    • Membership Application
    • Membership Benefits
    • Membership Types
      • Requirements and Applications for Active Membership in SAGES
      • Requirements and Applications for Affiliate Membership in SAGES
      • Requirements and Applications for Associate Active Membership in SAGES
      • Requirements and Applications for Candidate Membership in SAGES
      • Requirements and Applications for International Membership in SAGES
      • Requirements for Medical Student Membership
    • Member Spotlight
    • Give the Gift of SAGES Membership
  • Patients
    • Join the SAGES Patient Partner Network (PPN)
    • Patient Information Brochures
    • Healthy Sooner – Patient Information for Minimally Invasive Surgery
    • Choosing Wisely – An Initiative of the ABIM Foundation
    • All in the Recovery: Colorectal Cancer Alliance
    • Find A SAGES Surgeon
  • Publications
    • Clinical / Practice / Training Guidelines, Statements, and Standards of Practice
    • Sustainability in Surgical Practice
    • SAGES Stories Podcast
    • Patient Information Brochures
    • Patient Information From SAGES
    • TAVAC – Technology and Value Assessments
    • Surgical Endoscopy and Other Journal Information
    • SAGES Manuals
    • MesSAGES – The SAGES Newsletter
    • COVID-19 Archive
    • Troubleshooting Guides
  • Education
    • Wellness Resources – You Are Not Alone
    • Avoid Opiates After Surgery
    • SAGES Subscription Catalog
    • SAGES TV: Home of SAGES Surgical Videos
    • The SAGES Safe Cholecystectomy Program
    • Masters Program
    • Resident and Fellow Opportunities
      • MIS Fellows Course
      • SAGES Robotics Residents and Fellows Courses
      • SAGES Free Resident Webinar Series
      • Fluorescence-Guided Surgery Course for Fellows
      • Fellows’ Career Development Course
    • SAGES S.M.A.R.T. Enhanced Recovery Program
    • SAGES @ Cine-Med Products
      • SAGES Top 21 Minimally Invasive Procedures Every Practicing Surgeon Should Know
      • SAGES Pearls Step-by-Step
      • SAGES Flexible Endoscopy 101
    • SAGES OR SAFETY Video Activity
  • Opportunities
    • Fellowship Recognition Opportunities
    • SAGES Advanced Flexible Endoscopy Area of Concentrated Training (ACT) SEAL
    • Multi-Society Foregut Fellowship Certification
    • Research Opportunities
    • FLS
    • FES
    • FUSE
    • Jobs Board
    • SAGES Go Global: Global Affairs and Humanitarian Efforts
  • OWLS/FLS
You are here: Home / Abstracts / Evaluation of Abdominal Wall Remodeling Following Ventral Hernia Formation in a Rodent Model

Evaluation of Abdominal Wall Remodeling Following Ventral Hernia Formation in a Rodent Model

David M Krpata, MD, Karem C Harth, MD, Jeffrey A Blatnik, MD, Michael J Rosen, MD. Case Comprehensive Hernia Center, University Hospitals Case Medical Center

 

Introduction: Mediating abdominal wall function, the linea alba is a major tendinous insertion for abdominal wall musculature. When tendons are severed in limb muscles, changes classic for disuse atrophy appear. Similarly, when a ventral hernia occurs, particularly following a midline laparotomy, the linea alba attachment is lost and abdominal wall muscles may laterally retract and potentially undergo disuse atrophic changes. The objective of this study was to evaluate in a rat model the abdominal wall remodeling that occurs after the unloading of the core abdominal wall musculature with ventral hernia formation.
 

Methods: The linea alba of Sprague-Dawley rats were incised and rats were survived for 30 days to represent a model of chronic ventral hernia. At 30 days, abdominal wall samples were evaluated for changes in muscle fiber type and size with histologic analysis, changes in muscle biomechanics and changes in gene expression with Affymetrix GeneChips to potentially associate downstream effects of ventral hernias with abdominal wall remodeling.
 

Results: In total, 10 Sprague-Dalwey rats underwent hernia formation (Hernia) and were compared 10 Sprague Dawley normal abdominal walls (Control). Mean size of the hernia defects at 30 days was 4.52 cm2 (range 2.5-6 cm2). On histologic analysis, there was no significant difference in number of Type I muscle fibers or Type I fiber total percent area in either the external abdominal oblique muscles (Control: 413 fibers ± 216; 4.62% ± 1.29: Hernia: 481 ± 297 fibers; 5.11% ± 1.56) (p=0.30; p=0.18) or internal abdominal oblique muscles (Control: 311 fibers ± 241, 5.96% ± 1.25; Hernia: 442 fibers ± 231, 6.03 ± 1.90) (p=0.06, p=0.88). The biomechanical properties of unloaded and normal abdominal walls were similar in tensile strength (Control: 1.90 N/mm2 ± 0.72; Hernia: 1.82 N/mm2 ±0.38) (p=0.71), toughness (Control: 126.37 J ± 48.18; Hernia: 105.89 J ± 25.37) (p=0.16), and stiffness (Controls: 1.05 N/mm ± 0.5; Hernia: 1.00 N/mm ± 0.30) (p= 0.77). After RNA isolation, gene expression was significantly different in only a single gene out of the over 30,000 genes analyzed.
 

Conclusions: Abdominal musculature of Sprague Dawley rats at 30 days following ventral hernia formation does not show significant changes in muscle typing, biomechanical properties or gene expression as would be expected with abdominal wall remodeling. Although literature supports a rat model to investigate the disuse atrophy associated with limb muscle unloading, this does not appear to hold consistent with abdominal wall musculature. Additional models should be investigated to evaluate the abdominal wall remodeling likely associated with functional changes seen in humans who have developed ventral hernias.
 


Session Number: Poster – Poster Presentations
Program Number: P290
View Poster

247

Share this:

  • Click to share on X (Opens in new window) X
  • Click to share on Facebook (Opens in new window) Facebook
  • Click to share on LinkedIn (Opens in new window) LinkedIn
  • Click to share on Pinterest (Opens in new window) Pinterest
  • Click to share on WhatsApp (Opens in new window) WhatsApp
  • Click to share on Reddit (Opens in new window) Reddit
  • Click to share on Pocket (Opens in new window) Pocket
  • Click to share on Mastodon (Opens in new window) Mastodon
  • Click to share on Threads (Opens in new window) Threads
  • Click to share on Bluesky (Opens in new window) Bluesky

Related


sages_adbutler_leaderboard

Hours & Info

11300 West Olympic Blvd, Suite 600
Los Angeles, CA 90064

1-310-437-0544

[email protected]

Monday – Friday
8am to 5pm Pacific Time

Find Us Around the Web!

  • Bluesky
  • X
  • Instagram
  • Facebook
  • YouTube

Copyright © 2025 · SAGES · All Rights Reserved

Important Links

Healthy Sooner: Patient Information

SAGES Guidelines, Statements, & Standards of Practice

SAGES Manuals