Background: Roux-en-Y gastric bypass (RYGB) results in rapid weight loss and improvement of associated co-morbidities; however, a significant number of patients regain weight. We hypothesize that co-morbidities will recur in patients who regain weight.
Methods: In this retrospective study, 52 patients who presented with weight regain were analyzed, along with their co-morbidities. Predictors for co-morbidity return were also determined. Statistical analysis was performed by Student’s t-test.
Results: Average BMI before and after RYGB in all 52 patients was 52.6 kg/m2 and 33.7kg/m2, respectively. Diabetes (DM), hypertension (HTN), hyperlipidemia (HL), and obstructive sleep apnea (OSA) resolved/improved in 83, 52, 33, and 52% of patients, respectively, after the original gastric bypass. After a mean regain of 44.0 +/- 3.3lbs at a mean follow-up of 5.4 years, 60, 53, 43, and 40% of patients experienced recurrence or worsening of DM, HTN, HL, and OSA. Predictors for recurrence included older age and higher BMI pre- or post-RYGB. Length of time after RYGB, gender, and race were not predictors of co-morbidity recurrence.
Conclusion: In this study we have analyzed data from 52 patients who regained weight lost following RYGB and found that a significant number of patients experience recurrence of obesity-related conditions. Interestingly, not all co-morbidities return with weight regain. Older age and higher BMI predispose patients who regain weight to recurrent co-morbid conditions.
Program Number: P049