C-reactive protein concentrations before and after gastric bypass surgery inversely correlate with omental gene expression of adiponectin.

Adipose tissue is a key regulator of C-reactive protein (CRP), an inflammatory marker linked to atherosclerosis. Adiponectin, the most abundant adipokine is also an importantl factor involved in the inflammatory state of obesity. The aim of the study was to assess the impact of gastric bypass surgery (GBS) on the CRP levels and its relation to adipose tissue expression of adiponectin. Methods: Omental and subcutaneous fat biopsies and plasma were obtained from 30 subjects undergoing GBS and 10 subjects after GBS (> 12 months postop). Adiponectin gene expression was measured by quantitative PCR and normalized for GAPDH. CRP was measured by a high-sensitivity assay. Results:Omental adiponectin was lower and CRP higher in the group undergoing GBS than in the post-GBS (adiponectin, 0.75±0.5 vs 1.41±0.44, p=0.0004; CRP, 1009±951 vs 120±114 ng/ml, p=0.005). As shown in the figure, multivariate analysis revealed that CRP independently correlates with omental adiponectin (r= -0.703, P=0.001) but not with subcutaneous adiponectin. Conclusions: CRP significantly decreases after GBS upholding a significant negative correlation with omental adiponectin. According to these findings omental adiponectin is a potential mechanism linking obesity with atherosclerosis.

Session: Podium Presentation

Program Number: S023