Carla Holcomb, MD, MSPH, Lauren Goss, MSPH, Amandiy Liwo, MD, MSPH, Jayleen Grams, MD, PhD, Ammar Almehmi, MD, MSPH, Richard Stahl, MD, Britney Corey, MD. University Of Alabama At Birmingham
Introduction: Weight loss after bariatric surgery has been shown to improve both blood pressure and glycemic control following surgery. However, the effect of bariatric surgery on renal function is not well characterized. In this study, we sought to quantify the change in renal function over two years following surgery.
Methods: We retrospectively reviewed all patients who underwent laparoscopic Roux-en-Y gastric bypass (LRYGB) or laparoscopic sleeve gastrectomy (LSG) between 2012 and 2014 at our institution. Estimated glomerular filtration rate (eGFR, ml/min/1.73m2) was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Body mass index (BMI, kg/m2) and percent weight loss were calculated following surgery. Linear regression models were used to predict postoperative eGFR.
Results: A total of 149 patients who underwent bariatric surgery were included in this study: LRYGB (n=85) and LSG (n=64). In LRYGB group, baseline BMI (kg/m2, ± SD) and eGFR (ml/min/1.73m2, ± SD) were 48.3 ± 8.0 and 95.2 ± 23.8, respectively. In comparison, BMI and eGFR were 47.9 ± 9.6 kg/m2 and 93.4 ± 27.5 ml/min/1.73 m2 in the LSG group. During the study follow up period (19.25 ±10.5 months), the patients who underwent LRGYB lost a larger percentage of weight as compared to those in the LSG group (29.9% ±11.7% vs 21.8% ±10.8%; p=<.0001) (Figure 1A). Overall, eGFR improved in both LRYGB and LSG groups 2 years after the surgery (106.0 ± 23.4 ml/min/1.73 m2 vs 103.7 ± 23.5 ml/min/1.73 m2 respectively). However, there was no statistically significant difference in eGFR noted between the two groups (Figure 1B, p=0.4354). Interestingly, there was no relationship between percent weight loss and eGFR improvement (p=0.8703).
Conclusions: Bariatric surgery was associated with improvement in postoperative renal function at two years following surgery. The gain in eGFR was independent of percent weight loss.
.JPG)
Presented at the SAGES 2017 Annual Meeting in Houston, TX.
Abstract ID: 80440
Program Number: S017
Presentation Session: Bariatric and Metabolic Surgery
Presentation Type: Podium