• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
  • Skip to footer

SAGES

Reimagining surgical care for a healthier world

  • Home
    • COVID-19 Annoucements
    • Search
    • SAGES Home
    • SAGES Foundation Home
  • About
    • Who is SAGES?
    • SAGES Mission Statement
    • Advocacy
    • Strategic Plan, 2020-2023
    • Committees
      • Request to Join a SAGES Committee
      • SAGES Board of Governors
      • Officers and Representatives of the Society
      • Committee Chairs and Co-Chairs
      • Full Committee Rosters
      • SAGES Past Presidents
    • Donate to the SAGES Foundation
    • Awards
      • George Berci Award
      • Pioneer in Surgical Endoscopy
      • Excellence In Clinical Care
      • International Ambassador
      • IRCAD Visiting Fellowship
      • Social Justice and Health Equity
      • Excellence in Community Surgery
      • Distinguished Service
      • Early Career Researcher
      • Researcher in Training
      • Jeff Ponsky Master Educator
      • Excellence in Medical Leadership
      • Barbara Berci Memorial Award
      • Brandeis Scholarship
      • Advocacy Summit
      • RAFT Annual Meeting Abstract Contest and Awards
  • Meetings
    • NBT Innovation Weekend
    • SAGES Annual Meeting
      • 2023 Scientific Session Call For Abstracts
      • 2023 Emerging Technology Call For Abstracts
    • CME Claim Form
    • Industry
      • Advertising Opportunities
      • Exhibit Opportunities
      • Sponsorship Opportunities
    • Future Meetings
    • Past Meetings
      • SAGES 2022
      • SAGES 2021
    • Related Meetings Calendar
  • Join SAGES!
    • Membership Benefits
    • Membership Applications
      • Active Membership
      • Affiliate Membership
      • Associate Active Membership
      • Candidate Membership
      • International Membership
      • Medical Student Membership
    • Member News
      • Member Spotlight
      • Give the Gift of SAGES Membership
  • Patients
    • Healthy Sooner – Patient Information for Minimally Invasive Surgery
    • Patient Information Brochures
    • Choosing Wisely – An Initiative of the ABIM Foundation
    • All in the Recovery: Colorectal Cancer Alliance
    • Find a SAGES Member
  • Publications
    • SAGES Stories Podcast
    • SAGES Clinical / Practice / Training Guidelines, Statements, and Standards of Practice
    • Patient Information Brochures
    • TAVAC – Technology and Value Assessments
    • Surgical Endoscopy and Other Journal Information
    • SAGES Manuals
    • SCOPE – The SAGES Newsletter
    • COVID-19 Annoucements
    • Troubleshooting Guides
  • Education
    • OpiVoid.org
    • SAGES.TV Video Library
    • Safe Cholecystectomy Program
      • Safe Cholecystectomy Didactic Modules
    • Masters Program
      • SAGES Facebook Program Collaboratives
      • Acute Care Surgery
      • Bariatric
      • Biliary
      • Colorectal
      • Flexible Endoscopy (upper or lower)
      • Foregut
      • Hernia
      • Robotics
    • Educational Opportunities
    • HPB/Solid Organ Program
    • Courses for Residents
      • Advanced Courses
      • Basic Courses
    • Video Based Assessments (VBA)
    • Robotics Fellows Course
    • MIS Fellows Course
    • Facebook Livestreams
    • Free Webinars For Residents
    • SMART Enhanced Recovery Program
    • SAGES OR SAFETY Video
    • SAGES at Cine-Med
      • SAGES Top 21 MIS Procedures
      • SAGES Pearls
      • SAGES Flexible Endoscopy 101
      • SAGES Tips & Tricks of the Top 21
  • Opportunities
    • NEW-Area of Concentrated Training Seal (ACT)-Advanced Flexible Endoscopy-Coming Soon!
    • SAGES Fellowship Certification for Advanced GI MIS and Comprehensive Flexible Endoscopy
    • Multi-Society Foregut Fellowship Certification
    • SAGES Research Opportunities
    • Fundamentals of Laparoscopic Surgery
    • Fundamentals of Endoscopic Surgery
    • Fundamental Use of Surgical Energy
    • Job Board
    • SAGES Go Global: Global Affairs and Humanitarian Efforts
  • Search
    • Search All SAGES Content
    • Search SAGES Guidelines
    • Search the Video Library
    • Search the Image Library
    • Search the Abstracts Archive
  • Store
    • “Unofficial” Logo Products
  • Log In

Ab Prep a New Colon Cleansing

AB Prep: colon cleansing made easier
With the colonoscopy being the main procedure that evaluates and prevents colon cancer; efforts to make the experience tolerable and pleasant has always been a priority and a challenge.
In the United States out of all the people meeting the criteria for screening colonoscopy only 35% of the people actually undergo the procedure. Therefore, thousands of people still develop colon cancer and die unnecessarily.
The AB Prep is made out of three FDA approved generic medications. The mechanism of cleansing is a combination of osmotic and stimulant laxatives ).
A total of 16 tablets taken over two main steps.
Clinincal trial was conducted to evaluate the safety and efficacy of the prep.
1-Patients’ electrolytes including Glucose, Sodium, Potassium, Chloride, Bun, Creatinine, Co2, Calcium, Alkaline Phosphotase, ALT, AST, Magnesium, and Phosphorus, EKG with QTc were compared before and after Prep consumption.
2-In addition subjective data was collected from the patients to grade compliance, satisfaction, abdominal bloating, abdominal pain, nausea, and vomiting, also would they recommend the prep to their family members and friends.

3-To objectively grade the colon cleansing, the colon cleansing was divided into either achieved or not achieved. A picture of the colon was obtained at the end of the procedure to document the colonic mucosa appearance in the cecum, transverse, left colon, and the rectum; the amount of irrigation used to achieve the final cleansing and the duration of the procedures were documented, and graphed, presenting an objective reproducible grading of the cleansing.
A total of 200 patients were evaluated in phase II: 54% women and 46% men, with the mean age of 61, and included patients with hypertension, diabetes, renal, cardiac, pulmonary, liver and or seizure disorder. SPSS program was used to evaluate the data.
Results: The prep was noted to be 99.5% effective, 89% had excellent to good cleansing (the mean average plus a standard deviation) and 10.5% had fair cleansing. There was an excellent tolerability, with 100% compliance, 100% satisfaction, 1.5% had abdominal pain, 1.5% abdominal bloating, 2% had nausea, and none had any vomiting.
The electrolytes, QTc interval and EKG remained within normal limits throughout the study with:
-No statistically significant changes noted in:
1-Creatinine 2-Sodium 3-Chloride 4-CO2 5-Calcium 6-Alk Phos. 7-Magnesium 8-Phosphorus
-Statistically significant changes after taking the Prep were noted in:
1-Glucose 8% decrease 2-Bun 23.6% decrease 3- Potassium 3.87% decrease 4-AST 12.6% increase 5-ALT 8.5% increase 6-QTC 2.4% increase, (on the average).
The most important finding throughout phase I and Phase II, that despite the statistical significant changes noted; all the variables studied remained within normal limits. That safety profile was also observed in patients with cardiac, hypertension, renal, diabetes, and seizure disorder.
Patients with severe constipation (One bowel movement per week or more, or one bowel movement every three days or more with the help of laxatives) were treated with two days prep, and the same safety profile was observed.
Conclusion: Although The AB Prep is an effective colon cleansing as the rest of the available preparation; it does however, offer an excellent unmatched safety profile with minimal side effects even when it is taken over two days, with no contraindication even in patients with renal disease. Furthermore, it could be used as a safe and an effective treatment for patients with severe chronic constipation.


Session: Podium Presentation

Program Number: S044

76

Share this:

  • Twitter
  • Facebook
  • LinkedIn
  • Pinterest
  • WhatsApp
  • Reddit

Related

« Return to SAGES 2009 abstract archive

Our Mission

Innovate, educate and collaborate to improve patient care.

Recently, on SAGES…

Critical View of Safety (CVS) Challenge QR Code

The SAGES Critical View of Safety Challenge – Donate Your Lap Chole Videos!

The Society of American Gastrointestinal and Endoscopic Surgeons is hosting the first Artificial Intelligence Data Challenge conducted by surgeons. The aim of this challenge is to generate a large and diverse dataset of laparoscopic cholecystectomy videos, annotated with respect to the subcomponents of the Critical View of Safety (CVS). Computer scientists from all over the […]

Respuesta de SAGES al Estudio NordICC sobre el beneficio de las colonoscopias de detección

SAGES desea aclarar los resultados del estudio NordICC y colocarlos en contexto de los esfuerzos de varias agencias nacionales para reducir el riesgo de cáncer colorrectal – la segunda causa de muerte por cáncer más frecuente en los Estados Unidos-, mediante la promoción de la detección y tratamiento oportuno de las lesiones.

SAGES Response to NordICC Study Regarding Benefit of Screening Colonoscopies

The NordICC Study recently published in The New England Journal of Medicine and widely reported on by media outlets has raised questions regarding the benefit of screening colonoscopy in lowering the risk of colorectal cancer and cancer-related deaths among otherwise healthy and symptom-free men and women aged 55 to 64. Provocative headlines and commentaries have […]

Contact SAGES

Society of American Gastrointestinal and Endoscopic Surgeons
11300 W. Olympic Blvd Suite 600
Los Angeles, CA 90064 USA
webmaster@sages.org
Tel: (310) 437-0544

Find Us Around the Web!

  • Facebook
  • Twitter
  • YouTube

Important Links

SAGES 2023 Meeting Information

Healthy Sooner: Patient Information

SAGES Guidelines, Statements, & Standards of Practice

SAGES Manuals

 

  • taTME Study Info
  • Foundation
  • SAGES.TV
  • MyCME
  • Educational Activities

Copyright © 2023 Society of American Gastrointestinal and Endoscopic Surgeons