Michiya Kobayashi, MD1, Takashi Anayama, MD1, Ryohei Miyazaki, MD1, Kentaro Hirohashi, MD1, Nobutaka Kawamoto, MD1, Masashi Yoshida, MD2, Masaki Kitajima, MD2, Hiromi Sato, RN3, Takayuki Sato, MD1. 1Kochi Medical School, 2International University of Health and Welfare, 3PlusMed Co., Ltd.
Backgrounds: We have succeeded in developing a new near-infrared fluorescent (NIRF) dye that can be incorporated into polymer. The NIRF dye has high thermal resistance, suitability for hot melt mixing with polymer, high quantum yield more than 40%, and an emission wavelength of 800-850 nm. Here we reported on an application of the NIRF polymer to endoscopically clipping markers.
Methods and Results: The clipping marker was fabricated by modification of a commercially available hemostatic clip for endoscope. The stainless-steel tube that was slidably attached to the clip body and worked as a fastening tool of the clip arms, was replaced with the NIRF-polymer tube. The luminance of NIRF of the clipping marker was 30 times higher than that of indocyanine green aqueous solution (8 ppm). The clipping markers were endoscopically placed on the mucosal surface of a porcine digestive tract. Under laparoscopic observation with an NIRF imaging camera (Image 1, Karl Storz), all of the positions of the clipping markers on the mucosal surface of the esophagus, stomach, and colon were quickly and easily pinpointed from the serosal side.
Conclusions: Our NIRF polymer is a promising material for endoscopically clipping markers pinpointable by laparoscopy.
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Presented at the SAGES 2017 Annual Meeting in Houston, TX.
Abstract ID: 91059
Program Number: ETP856
Presentation Session: Emerging Technology iPoster Session (Non CME)
Presentation Type: Poster