Diagnostic and prognostic value of circulating tumor DNA in gastric cancer: a meta-analysis
Yunhe Gao, Kecheng Zhang, Hongqing Xi, Aizhen Cai, Xiaosong Wu, Jianxin Cui, Jiyang Li, Zhi Qiao, Bo Wei, Lin Chen. Chinese People's Liberation Army of General HospitalBackground: Circulating tumor DNA (ctDNA) has offered a minimally invasive approach for detection and measurement of gastric cancer (GC). However, its diagnostic and prognostic value in GC still remains… Continue Reading
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- Basic Science
Evaluation of a MicroRNA-124 Inhibitor as a Potential Therapy for Gulf War Illness Using an Established Rat Model
C.t. Grayson, MD, MPH, Wendy Kurata, MS, Karen Matsumoto, Lisa Pierce, DSc. Tripler Army Medical CenterObjectives: Gulf War Illness (GWI) is a chronic, multisystem illness marked by cognitive and mood dysfunction that affects up to 30% of GW veterans. The diagnosis remains elusive, useful treatments are lacking, and the cause is poorly understood, although exposures… Continue Reading
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- Basic Science
Fundamental principles of ancient Indian surgery with a special emphasis on plastic surgery – A review of Susrutha samhita (800 BC)
Bhaskar Rao, PhD1, Harsha vardhan Appaji K, MD1, Vasishta Martha, MBBS2. 1SV AYURVEDIC MDICAL COLLEGE, 2PES Institute of medical sciences and ResearchSusrutha (800 BC) is a legendary scholar of Indian surgical science and founding father of ancient surgery. 2600 years ago, Susrutha together with his colleagues had conducted a variety of complex surgeries such as… Continue Reading
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- Basic Science
Graft-implanted Tacrolimus-Eluting Hydrogels Prolong Survival after Vascularized Composite Allotransplantation
Kevin Wu1, Renford Cindass2, Lin Wang2, Sharon Lawson3, Jeffrey Karp4, Nitin Joshi4, Praveen Vemula5, Vijay Gorantla6, Michael Davis7. 1RESTOR™ Program, 59th Medical Wing, JBSA Lackland AFB, TX, 2San Antonio Military Medical Center, JBSA Fort Sam Houston, TX, 3University of Texas Health Sciences Center at San Antonio, 4Brigham & Women’s Hospital, Harvard Medical School, 5Institute for… Continue Reading
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- Basic Science
Gram-Negative Bacterial Infection Enhances the Potential of Gastric Adenocarcinoma Peritoneal Metastasis via TNFR1 Dependent Manner
Malak Alzahrani, MD, MSc, Rafael Kayano, Betty Giannias, France Bourdeau, Roni Rayes, Lorenzo Ferri, MD, PhD. McGill UniversityAdenocarcinoma of the proximal stomach is the fastest rising malignancy in North America, and is associated with a high rate of recurrence to the peritoneum. As part of cancer treatment, the majority of patients undergo at least one… Continue Reading
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- Basic Science
Hydrogels and fistulas: a promising liaison
P Riva, MD1, G Alonci2, F Fiorini2, B Dallemagne, MD3, J Marescaux, MD, FACS, Hon, FRCS, Hon, FJSES, Hon, APSA3, L De Cola, Prof2, S Perretta, MD, PhD3. 1Institute of Image-Guided Surgery (IHU Strasbourg), c/o IRCAD, Strasbourg (France), 2Institut de Science et d'Ingénierie Supramoléculaires, Université de Strasbourg, Strasbourg (France), 3IRCAD, Institut de Recherche contre les… Continue Reading
- Topic:
- Basic Science
Hyperbaric Normothermic Perfusion Mitigates Reperfusion Injury in Porcine Vascular Composite Allotransplantation (VCA)
Nicholas Robbins1, Kevin Y Wu1, Renford Cindass2, Sharon Lawson3, Lin Wang2, George E Wolf1, Michael Davis, MD1. 1RESTOR™ Program, 59th Medical Wing, JBSA Lackland AFB, TX, 2San Antonio Military Medical Center, JBSA Fort Sam Houston, TX, 3University of Texas Health Sciences Center at San AntonioObjective: Modern body armor, rapid evacuation and advanced combat casualty care… Continue Reading
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- Basic Science
Impact of a Novel Pi3-kinase Inhibitor in Preventing Mitochondrial Dna Damage and Damage Associated Molecular Pattern Accumulation: Results from the Biochronicity Project
G E Black, MD1, K K Sokol, MD1, D M Moe1, J Simmons, MD2, D Muscat, BS2, V Pastukh, PhD2, G Capley, MS2, O Gorodnya, MS2, M Ruchko, PhD2, M Gillespie, PhD2, M J Martin, MD1. 1Madigan Army Medical Center, 2University of South AlabamaOBJECTIVES: Despite improvements in the management of severely injured patients, development of… Continue Reading
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- Basic Science
Inflammatory mediators and signalling cascades in pathophysiology of obesity induced insulin resistance
Saravanan Subramanian, PhD, Turna Mukherjee, Pradeep K Pallati, MD, Poonam Sharma, MD, Devendra Agrawal, PhD, Kalyana C Nandipati, MD. Creighton University School of MedicineIntroduction: Adipocyte induced pro-inflammatory cytokines and chemokines activates pathogenic inflammatory cells receptors and stimulates inflammatory signalling pathways that result in obesity induced insulin resistance. However, exact role of cell surface receptors and… Continue Reading
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- Basic Science
Long non-coding RNA AFAP1-AS1 promotes the proliferation, migration and invasion of gastric cancer cells and is associated with patients’ poor survival
Huazhou Zhao1, Ting Wang2, Kecheng Zhang3, Jianxin Cui3, Hongqing Xi3, Bo Wei3, Yi Wang1, Xudong Zhao3, Yanjing Song3, Lin Chen3. 1Chinese People's Liberation Army of General Hospital & Department of General Surgery, 309 Hospital of Chinese People’s Liberation Army, 2Medical administration division of Beijing Chaoyang Hospital, Beijing, China, 3Chinese People's Liberation Army of General HospitalBackgroud… Continue Reading
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- Basic Science
Mechanisms of Diabetic Remission after Sleeve Gastrectomy: Increases in L-cell Mediated Incretin Response, Insulin Release, and Sensitivity.
Devon Hawkins, MD, Balakrishna Prasad, PhD, Rebekah Johnson, MD, Matthew Pierotti, MD, William Sherman, MD, Byron Faler, MD, Yong Choi, MD. Eisenhower Army Medical CenterBackground: Sleeve gastrectomy is regarded as an effective intervention for both obesity and comorbid conditions such as diabetes. However, the mechanisms underlying diabetes remission after sleeve gastrectomy are not well understood.… Continue Reading
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- Basic Science
Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species
Wenquan Liang, Aizhen Cai, Hongqing Xi, Guozhu Chen, Xiaosong Wu, Jianxin Cui, Kecheng Zhang, Xudong Zhao, Jiyun Yu, Bo Wei, Lin Chen. Chinese People's Liberation Army of General HospitalObjectives The prognosis of gastric cancer remains poor due to clinical drug resistance. Shikonin (SHK), a natural naphthoquinone, has been reported to trigger cell death and overcome… Continue Reading
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- Basic Science
Should electrocautery be used for hemostasis of sleeve gastrectomy staple line or not? This study concerns histological alteration of a gastric wall after electrocauterization on staple line.
Jakrapan Wittayapairoch, MD1, Sakkran Sangkhamanon, MD2, Narong Boonyagard, MD3, Rapheephat Tanomphetsanga, MD3, Kongpon Tangpanitandee, MD3, Krit Kitisin, MD3, Suppa-ut Pungpapong, MD3, Chadin Tharavej, MD3, Patpong Navicharern, MD3, Suthep Udomsawaengsup, MD3. 1Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, 2Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, 3Department… Continue Reading
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- Basic Science
Simvastatin Enhances Radiation Sensitivity of Colorectal Cancer by Targeting Colorectal Cancer Initiating Cells
Georgios Karagkounis, Jennifer DeVecchio, BA, Sylvain Ferrandon, PhD, Matthew F Kalady, MD. Cleveland ClinicIntroduction: Neoadjuvant chemoradiation (CRT) for rectal cancer induces variable responses, and better response has been associated with improved oncologic outcomes. Our group has previously shown that administration of HMG-CoA reductase inhibitors, commonly known as statins, is associated with improved response to neoadjuvant… Continue Reading
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- Basic Science
The Systemic Effect and The Absorption Rate of Aerosolized Intra-peritoneal Heparin With or Without Hyaluronic Acid in the Prevention of Postoperative Abdominal Adhesion
Ahmed Almamar, MD, MSc, FRCSC, Nawar Alkhamesi, MD, PhD, FRCS, FRCSED, FRCSC, Christopher M Schlachta, BSc, MDCM, FRCSC, FACS. Western University and Canadian Surgical Technologies and Advanced Robotics (CSTAR), London, CanadaIntroduction: Adhesions are a cause of morbidity following surgery. Multiple approaches have been evaluated to minimize them. Aerosolized heparin and hyaluronic acid is an effective… Continue Reading
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- Basic Science