Bile reflux induced mutagenesis on esophageal epithelium in an animal model and its effect in cell signaling
BILE REFLUX INDUCED MUTAGENESIS ON ESOPHAGEAL EPITHELIUM IN AN ANIMAL MODEL AND ITS EFFECT IN CELL SIGNALING Ben Selvan MS, Anu Korula MD, Anoop Ramachandran PhD, Jaya kumar MSc, Sathish Kumar MSc, George MS, Christian Medical College ,Vellore Background: . Bile reflux has been suggested to have a mutagenic effect on esophageal epithelium. However, signaling… Continue Reading
- Type:
- Posters
- Topic:
- Basic Science
Evaluation of Influence of Pneumoperitoneum on the Abdominal Solid Organs By Microdialysis: Experimental Study
Background: Nowadays, laparoscopic surgery has feasibility of partial liver resection and pancreatectomy because of less invasion than a conventional open operation. It is known increased intra-abdominal pressure on the liver and on the pancreas induce reduction of micro- and macro-circulation and this cause severe damage on splanchnic organs. However there is not enough monitoring method… Continue Reading
- Type:
- Posters
- Topic:
- Basic Science
Decreased expression of hepatic signaling phosphoproteins after laparoscopic and hand-Assisted surgery
Background: Minimally-invasive surgery is associated with a decreased activation of both systemic and peritoneal immunity as compared to the open (O) technique. However, the hepatic response to laparoscopic (L) and hand-assisted (HA) surgery has not been defined well. We postulated that both laparoscopic and hand-assisted approaches are associated with a diminished expression of hepatic pro-inflammatory… Continue Reading
- Type:
- Posters
- Topic:
- Basic Science
Inflammatory Response to NOTES Transgastric Surgery
Study Aim: The risk of gastric spillage during transgastric surgery is a concerning potential complication of NOTES procedures. The aim of this study is to determine the risk of sepsis from gastric spillage in a rat survival model by measuring local and systemic inflammatory markers, adhesive disease, and clinical outcomes.Methods: Under IACUC approval, mini-laparotomy with… Continue Reading
- Type:
- Podium Presentations
- Topic:
- Basic Science
C-reactive protein concentrations before and after gastric bypass surgery inversely correlate with omental gene expression of adiponectin.
Adipose tissue is a key regulator of C-reactive protein (CRP), an inflammatory marker linked to atherosclerosis. Adiponectin, the most abundant adipokine is also an importantl factor involved in the inflammatory state of obesity. The aim of the study was to assess the impact of gastric bypass surgery (GBS) on the CRP levels and its relation… Continue Reading
- Type:
- Podium Presentations
- Topic:
- Basic Science
Surgically Created Taste Aversions Develop in Rats Following Roux-en-Y Gastric Bypass
Background: Effective non-surgical treatment of morbid obesity continues to elude the medical community. Capturing positive effects of Roux-en-Y gastric bypass (RYGB) without surgery may be essential in achieving this goal. We have previously shown that patients experience taste changes and aversions following RYGB. A rat model for RYGB can help define these changes as physiological… Continue Reading
- Type:
- Posters
- Topic:
- Basic Science
Potential Molecular Pathways involving the Resolution of Type II Diabetes following RYGB
Background: Following Roux-en-Y gastric bypass (RYGB), hyperglycemia dramatically improves in obese patients with Type II diabetes (T2D). For many patients, hypoglycemic agents and insulin are discontinued after RYGB. However, the exact mechanisms of this process are unknown. This unique study attempts to identify differences in gene expression profiles between pre- and post-operative T2D patients following… Continue Reading
- Type:
- Podium Presentations
- Topic:
- Basic Science
MIS Grasping Tools Cause Inflammation and Fibrin Deposition in Liver and Small Bowel
Introduction: Minimally Invasive Surgery (MIS) leads to a reduced sense of touch and diminished haptics (force feedback) in comparison to open surgery. This increases the potential for excessive force application during tissue manipulation. There are little data regarding tissue damage resulting from forces routinely applied in MIS. The purpose of this study is to systematically… Continue Reading
- Type:
- Posters of Distinction
- Topic:
- Basic Science
Dysregulation of Gene Expression within the PPAR pathway in Obese Patients
Background: The causes of obesity are multifactorial and may include dysregulation of certain genes, such as peroxisome proliferator activated receptor gamma (PPAR gamma). When activated, the PPAR gamma pathway promotes lipid metabolism. This study uses microarray technology to evaluate differential gene expression profiles in obese patients undergoing bariatric surgery versus non-obese controls. Methods: Blood samples… Continue Reading
- Type:
- Podium Presentations
- Topic:
- Basic Science
Chronic Aspiration Shifts the Immunue Response from Th-1 to Th-2 in a Murine Model of Asthma
Chronic aspiration associated with gastroesophageal reflux disease (GERD) is thought to play a substantial role in the development of asthma, the incidence of which is dramatically increasing in industrially developed countries. The majority of data examining the association between aspiration and asthma has been obtained from epidemiological studies, which show that between 50 and 90%… Continue Reading
- Type:
- Posters
- Topic:
- Basic Science
Does Elevated Gastric pH Affect the Detection of Gastroesophageal Reflux Using 24 hr Esophageal pH monitoring?
Introduction:24 hour esophageal pH is the most widely used method to quantify Gastroesophageal reflux (GER). GER may potentially be underestimated if the resting gastric pH is high. However, the value of routine assessment of gastric pH in the performance of 24hr esophageal pH monitoring is unclear. We studied normal subjects and symptomatic patients undergoing 24… Continue Reading
- Topic:
- Basic Science
The AirSeal TM : A new insufflation system for laparoscopic Surgery. Preliminary data concerning physiological changes.
Introduction:The physiopathologic consequences of pneumoperitoneum are well known. In the attempt to minimize CO2 peritonel uptake and the related physiological consequences, a new generation of insufflation systems and trocars are in development. This experimental animal study aims to assess the applicability and safety of a new insufflation and trocar system for laparoscopic surgery: the AirSeal… Continue Reading
- Type:
- Posters
- Topic:
- Basic Science
Real-Time Dynamics of Nitric Oxide within the Esophageal Wall
Objective: Current evidence suggests that the neurotransmitter Nitric Oxide (NO) plays a crucial role in the genesis of aboral propagative of esophageal peristalses during swallowing. However, direct evidence in this regard is lacking at present. The objective of this study was to measure changes in the level of NO within the intermuscular interstices of esophagus… Continue Reading
- Type:
- Podium Presentations
- Topic:
- Basic Science
Incisions Do Not Linearly Sum
Introduction: Critics of minimally invasive methods sometimes argue that the sum of lengths of all trocar sites are similarly morbid to a “conventional” incision of equal length. This argument assumes correctly that pain and scarring are proportional to total tension normal to a linear incision. But the argument also assumes that total tension sums linearly… Continue Reading
- Type:
- Posters
- Topic:
- Basic Science
Polypropylene mesh (PPM) or Light weight mesh (LWM) in inguinal hernia surgery (TEP)- results of a prospective randomized controlled study
Objectives of study-Mesh application in endoscopic hernia surgery is universal. Textile, weight and pore size of mesh continue to be debated. LWMs with larger pores seem to address the concerns of host response. Aim of this study was to evaluate the advantages if any of LWMs over PPMs in totally extraperitoneal (TEP) repair of inguinal… Continue Reading
- Type:
- Podium Presentations
- Topic:
- Basic Science