The effect of rs9939609 FTO Gene Polymorphism on weight loss after Laparoscopic Sleeve Gastrectomy

Ozgur Balasar1, Tugrul cakir2, Ozgur Erkal3, Arif Aslaner2, Bulent cekic4, Mehmet Uyar5, Nurullah Bulbuller, Ass, Prof, Dr2, Mehmet Tahir Oruc, Ass, Prof, Dr2. 1Department of Medical Genetics, Dr Faruk Sukan Maternity and Pediatric Hospital, Konya, TURKEY, 2General Surgery Department, Antalya Training and Research Hospital, Muratpa?a, Antalya, TURKEY, 3Medical Genetics, Antalya Training and Research Hospital, Muratpa?a, Antalya, TURKEY, 4Radiology, Antalya Training and Research Hospital, Muratpa?a, Antalya, TURKEY., 5Public Health, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, TURKEY

Purpose: Remarkable differences in weight loss have been observed in obese patients undergoing laparoscopic sleeve gastrectomy (LSG). These high variations might be partly explained by genetic factors. The rs9939609 fat mass and obesity-associated gene (FTO) polymorphism has been implicated in the susceptibility of obesity.

We aimed to explore the effects of the rs9939609 FTO gene polymorphism on weight loss among severely obese patients applying for laparoscopic sleeve gastrectomy (LSG).

Material and Methods: All individuals were analyzed for the FTO rs9939609 gene polymorphism. A total of 74 morbid obese patients (20 male, 54 female) were operated. Body weight and body mass index (BMI) were measured at before LSG and after surgery at the 6th month.

Results: Twenty-eight patients (37.8%) had genotype TT (wild type allel), 36 patients (48.6%) had genotype TA and 10 patients (13.5%) had genotype AA. In both wild type group and mutant group, BMI and weight levels decreased at the 6th month after surgery. Initial excess weight percent loss (IEWL) at 6 months of follow up was similar in both groups.

Conclusion: Our data showed that the rs9939609 FTO gene polymorphism is not a useful genetic test prior to LSG to help clinicians predicting the weight loss for severely obese patients in short-term follow up.

Key words: rs9939609 gene; polymorphism; FTO; laparoscopic sleeve gastrectomy; weight loss

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