Side-to-side Duodeno-colic Anastomosis with Endotract Tm Provides Excellent Weight Loss.

INTRODUCTION: Partial bypass of the GI tract may promote weight loss by decreased absorption of nutrients and changes in incretins. The aim of the study was to evaluate the safety and efficacy of performing a side-to-side duodeno-colic anastomosis with a new device called EndoTrack TM.
METHODS: Seven 40-50 Kg female Yorkshire pigs were allocated to a Duodeno-colic anastomosis (DCA) with an Endotract device TM, and were compared to a control group (SHAM). Swine’s weights were followed for 56 days. Gastroscopies were also performed at 8 and 28 days. Blood samples were also taken at regular intervals (CBC and Basic biochemistry profiles). At autopsy, gross changes and histological changes of the liver, duodenum and colic samples were performed.
RESULTS: While the SHAM group gained 33.2% more weight at 56 days, the DCA group had shown a weight loss of -18.2%, for a difference of 54.4% between the 2 groups (p < 0.05). On pig in each group developed an incisional hernia that required treatment and one pig in the DCA group had to be autopsied at day 6 for lethargy. No specific cause was identified for this lethargy (post surgical stress?). Histological examination of the anastomosis showed normal and smooth healing, with absence of liver toxicity.
CONCLUSION: Placement of an EndoTract safely and effectively creates an anastomosis between potions of the large and small bowel. The anastomosis that is created is robust and permanent, and facilitates a partial diversion of nutrient flow and thus alters the absorption of nutrients. In this porcine model with short follow-up, a side-to-side duodeno-colic anastomosis provided excellent weight loss without apparent nutritional or aberrant histological changes.

Session: Podium Presentation

Program Number: S056

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