High-resolution Manometry Findings in Healthy Volunteers With Bioview® Software

Masato Hoshino, Ananth Srinivasan, Tommy H Lee, Sumeet K Mittal. Creighton University Medical Center


INTRODUCTION: High-resolution manometry (HRM) is the current gold standard for evaluation of esophageal motility. There are three commercially available HRM systems, namely Sierra: Manoview®, MMS and Sandhill: Bioview®. A Chicago Classification has been proposed and widely accepted based on Manoview®. The objective of this study determine normal values using Bioview® (Sandhill Scientific Inc., Highland Ranch, CO, USA) and assess any differences.
METHODS AND PROCEDURES: After Institution Review Board (IRB) approval, fourteen healthy volunteers underwent HRM at Creighton University Medical Center (CUMC) between April 2010 and August 2010. The pressure topography parameters were analyzed using Chicago Classification for ten liquid and viscous swallows. Basal lower esophageal sphincter (LES) pressure, integrated relaxation pressure (IRP), distal contractile integral (DCI), contraction front velocity (CFV), transition zone (TZ) were calculated. Results were expressed as Median (IQR) and Mean±SD (SE). All statistical analyses were performed using SPSS version 17 (SPSS, Inc, Chicago, IL, USA).
RESULTS: The median (IQR) of basal LES pressure, IRP, DCI, CFV, and TZ was 26.4 (21.8-36.5) mmHg, 12.2 (8.8-14.7) mmHg, 2762 (2283-3051) mmHg-s-cm, 3.80 (3.46-4.09) cm/s, and 0.30 (0-1.0) cm respectively. Normative data presented at 5th and 95th was basal LES pressure (22.9-33.2 mmHg), IRP (9.8-15.3 mmHg), DCI (2241-3019 mmHg-s-cm), CFV (3.48-4.07 cm/s), and TZ (0-0.72 cm).
CONCLUSIONS: Normal values for Bioview® appear to be quite similar to those proposed in Chicago Classification using Manoview® and hence it seems reasonable to extrapolate normal values and subsequent classifications based on variations to the Bioview® analysis.

Session Number: Poster – Poster Presentations
Program Number: P547
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